Description

Diltiazem Hydrochloride CAS NO 103532-26-9 is a high-purity pharmaceutical active ingredient belonging to the calcium channel blocker class. It is a critical compound for the development and manufacturing of cardiovascular medications, primarily used to manage hypertension and angina pectoris. This product is essential for pharmaceutical manufacturers, research institutions, and compounding facilities requiring a reliable, high-quality API for formulation. Our supply chain is designed to meet the stringent demands of global pharmaceutical production.

Application

• Pharmaceutical API: Primary active ingredient in the manufacture of oral solid dosage forms (tablets, capsules) for cardiovascular therapy.
• Hypertension Treatment: Formulated into extended-release and immediate-release medications to manage high blood pressure.
• Angina Pectoris Management: Used in anti-anginal drugs to prevent chest pain caused by reduced blood flow to the heart.
• Cardiac Arrhythmia: Employed in certain formulations to control heart rate in specific arrhythmic conditions.
• Pharmaceutical Research & Development: Serves as a reference standard and key intermediate in the development of new drug delivery systems and generics.
• Compounding Pharmacy: Used by specialized pharmacies for preparing customized patient-specific medications where commercial formulations are unsuitable.

Basic Information

Product Name	Diltiazem Hydrochloride
CAS No.	103532-26-9
Molecular Formula	C22H26N2O4S • HCl
Molecular Weight	450.98 g/mol
Synonyms	Diltiazem HCl; (+)-cis-Diltiazem Hydrochloride; (2S,3S)-5-[2-(Dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-4,1,5-benzothiazepin-3-ol acetate hydrochloride; D-cis-Diltiazem Hydrochloride; Altiazem; Cardizem; Tiazac; Dilacor; Herbesser; Anginyl; CRD 401; Diltiazem Monohydrochloride
EINECS	Contact for details

Quality Control

Our Diltiazem Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity pharmaceutical standards, with specifications typically aligned with major pharmacopoeial guidelines. We provide full traceability and Certificates of Analysis (COA) are available for every shipment to guarantee identity, purity, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. Ensure the storage area is well-ventilated and separate from incompatible materials.

Specification

Item	Specification
Appearance	White or almost white, crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Optical Rotation	+115° to +120° (c = 1 in methanol)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.