Description

Rp-8-Bromo-Cyclic Amps (Sodium Salt) is a high-purity, biologically active nucleotide analog. This compound is critical for research in cellular signaling pathways, specifically as a potent and selective activator of cyclic AMP-dependent protein kinase (PKA). It serves as an essential tool for researchers and developers in the fields of biochemical research, pharmaceutical development, and molecular diagnostics. Its stability as a sodium salt form facilitates handling and formulation in aqueous-based experimental systems.

Application

• Biochemical Research: Used as a cell-permeable activator of Protein Kinase A (PKA) to study cAMP-mediated signal transduction pathways.
• Pharmaceutical R&D: Serves as a key reference standard and pharmacological tool in the discovery of drugs targeting PKA-related disorders.
• Cell Biology Studies: Employed to investigate the role of cAMP in cellular processes such as metabolism, gene expression, and ion channel regulation.
• Diagnostic Assay Development: Utilized in the development and calibration of high-throughput screening (HTS) assays for kinase activity.
• Neuroscience Research: Applied in studies of synaptic plasticity, memory, and neuronal function where PKA signaling is implicated.
• Enzymology: Acts as a substrate or modulator in enzymatic studies to characterize kinase and phosphodiesterase activities.

Basic Information

Product Name	Rp-8-Bromo-Cyclic Amps (Sodium Salt)
CAS No.	925456-59-3
Molecular Formula	C16H20BrN5NaO11P2 • xH2O
Molecular Weight	Contact for details
Synonyms	Rp-8-Br-cAMPS sodium salt; Rp-8-Bromo-adenosine-3',5'-cyclic monophosphorothioate sodium salt; 8-Bromo-Rp-cyclic AMPS sodium; Rp-8-Bromo-cAMPS; cAMP antagonist Rp-8-Br-cAMPS sodium; Adenosine, 8-bromo-cyclic 3',5'-(hydrogen phosphorothioate) Rp-isomer sodium salt; Rp-8-Bromo-cyclic adenosine monophosphorothioate sodium salt
EINECS	Contact for details

Quality Control

Our Rp-8-Bromo-Cyclic Amps (Sodium Salt) is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry for identity verification. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment ensures the reproducibility and reliability required for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, desiccate at -20°C. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.