Description

L-Ins(1,4,5)P3, 6K is a high-purity, cell-permeant derivative of the critical second messenger D-myo-inositol 1,4,5-trisphosphate (IP3). This compound is specifically engineered for research applications where precise modulation of intracellular calcium signaling is required. It is an essential tool for scientists in pharmacology, neuroscience, and cell biology investigating G-protein coupled receptor (GPCR) pathways, calcium release from endoplasmic reticulum stores, and related cellular processes.

Application

• Intracellular Calcium Signaling Research: Used as a research-grade agonist to study IP3 receptor-mediated calcium release from intracellular stores.
• GPCR and Phospholipase C (PLC) Pathway Studies: A key tool for investigating signal transduction pathways downstream of Gq-protein coupled receptors.
• Neuroscience Research: Applied in studies of synaptic plasticity, neurotransmitter release, and neuronal excitability where calcium acts as a secondary messenger.
• Cell Biology & Physiology: Utilized to probe calcium's role in processes such as muscle contraction, gene expression, and apoptosis.
• Drug Discovery & Screening: Serves as a reference compound and positive control in assays designed to identify modulators of the IP3 receptor for therapeutic development.
• Biochemical Assay Development: Employed in the standardization and validation of in vitro assays measuring IP3 receptor activity or calcium flux.

Basic Information

Product Name	L-Ins(1,4,5)P3, 6K
CAS No.	129828-71-3
Molecular Formula	C6H15O15P3
Molecular Weight	420.09 g/mol
Synonyms	L-myo-Inositol 1,4,5-trisphosphate, hexapotassium salt; L-IP3; Ins(1,4,5)P3; 1D-myo-Inositol 1,4,5-trisphosphate hexapotassium salt; D-myo-Inositol 1,4,5-trisphosphate (L-isomer) hexapotassium salt; Inositol 1,4,5-trisphosphate hexapotassium salt (L-form); IP3 hexapotassium salt
EINECS	Contact for details

Quality Control

Our L-Ins(1,4,5)P3, 6K is produced under strict quality management protocols to ensure batch-to-batch consistency and high chemical purity suitable for sensitive research applications. Each lot is characterized using advanced analytical techniques including HPLC and NMR to confirm identity and potency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, desiccate at the recommended temperature. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 98% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.