Description

Oncogene Protein Vav CAS NO 126141-95-5 is a critical signaling protein that functions as a guanine nucleotide exchange factor (GEF) for Rho family GTPases. It plays a pivotal role in regulating cytoskeletal dynamics, gene transcription, and cell proliferation, making it an essential tool for advanced life science research. This high-purity protein is primarily utilized by researchers in oncology, immunology, and cell signaling pathways to study cancer mechanisms, hematopoietic cell development, and immune receptor signaling.

Application

• Biochemical Research: Used as a key reagent in in vitro assays to study GEF activity, protein-protein interactions, and signal transduction cascades.
• Cancer Mechanism Studies: Essential for investigating the role of Vav proteins in oncogenic transformation, tumor progression, and metastasis.
• Immunology Research: Employed to elucidate signaling pathways downstream of T-cell and B-cell receptors, impacting immune cell activation and function.
• Drug Discovery & Screening: Serves as a target protein in high-throughput screening platforms to identify potential inhibitors of aberrant signaling in diseases.
• Enzymology Studies: Used to characterize the kinetic parameters and regulatory mechanisms of Rho GEF activity.
• Academic & Pharmaceutical R&D: A fundamental component for basic research and preclinical development within university laboratories and biopharmaceutical companies.

Basic Information

Product Name	Oncogene Protein Vav
CAS No.	126141-95-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Vav Oncoprotein; Vav Protein; Proto-Oncogene Vav; Guanine Nucleotide Exchange Factor VAV; VAV1 Oncogene; Vav Signaling Protein; p95Vav; Vav GEF
EINECS	Contact for details

Quality Control

Our Oncogene Protein Vav is produced under stringent conditions to ensure high purity and biological activity. Each batch undergoes comprehensive analytical testing, including SDS-PAGE, Western Blot, and functional activity assays. A detailed Certificate of Analysis (COA) documenting purity, concentration, and specific activity is provided to guarantee consistency and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C to -80°C. Avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or solution
Purity (SDS-PAGE)	≥ 90%
Identification (Western Blot)	Positive for Vav protein
Protein Concentration	As per COA (typically 0.1-1.0 mg/mL)
Biological Activity (GEF Assay)	Confirmed
Endotoxin Level (LAL Test)	< 1.0 EU/μg
Buffer Composition	Specified on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.