Description

(Cys0)-Adenylate Cyclase-Stimulating G-Alpha Protein (28-42) is a synthetic peptide fragment derived from the Gs alpha subunit, a key regulatory protein in cellular signaling. This high-purity research compound is specifically designed to stimulate adenylate cyclase activity, making it a critical tool for investigating G-protein-coupled receptor (GPCR) pathways and cyclic AMP (cAMP)-mediated signal transduction. It is essential for researchers and developers in pharmacology, biochemistry, and molecular biology who require precise and reliable bioactive peptides for target validation and mechanistic studies.

Application

• Biochemical Research: Used as a specific activator of adenylate cyclase in in vitro enzyme assays to study Gs protein function and kinetics.
• Signal Transduction Studies: A vital reagent for elucidating the cAMP-dependent signaling cascade downstream of GPCR activation in cell-based models.
• Drug Discovery & Target Validation: Serves as a reference standard and positive control in high-throughput screening (HTS) campaigns for identifying modulators of the Gs pathway.
• Academic & Pharmaceutical R&D: Fundamental for basic research on hormone action, neurotransmission, and metabolic regulation where Gs protein signaling is implicated.
• Diagnostic Kit Development: Can be utilized in the development of diagnostic assays that measure adenylate cyclase activity or cAMP production.

Basic Information

Product Name	(Cys0)-Adenylate Cyclase-Stimulating G-Alpha Protein (28-42)
CAS No.	101038-78-2
Molecular Formula	C73H118N22O23S
Molecular Weight	1687.9 g/mol
Synonyms	Gsα (28-42) peptide; GNAS (28-42); Adenylate Cyclase-Stimulating G-Alpha Protein Fragment (28-42); Gs alpha subunit stimulatory peptide; Gs stimulatory peptide; (Cys0)-GNAS1 (28-42); Gsα stimulatory fragment; Synthetic Gs protein activator peptide
EINECS	Contact for details

Quality Control

Every batch of our (Cys0)-Adenylate Cyclase-Stimulating G-Alpha Protein (28-42) is manufactured under stringent conditions and subjected to comprehensive analytical testing to ensure identity, purity, and biological activity. We adhere to ISO 9001 quality management principles. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming specifications for HPLC purity, amino acid analysis, mass spectrometry, and peptide content.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Analysis	Within ± 10% of theoretical composition
Solubility	Soluble in water or aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.