Description

C6 Nbd Safingol CAS NO 114301-97-2 is a specialized, fluorescently labeled derivative of safingol, a known modulator of sphingolipid metabolism. This compound is of significant value in biochemical and pharmacological research due to its utility as a molecular probe. It is primarily needed by research institutions and pharmaceutical companies engaged in lipid signaling studies, high-throughput screening, and the development of novel therapeutic agents targeting metabolic pathways.

Application

• Biochemical Research Probe: Used as a fluorescent tracer to study the cellular uptake, localization, and metabolism of sphingolipid analogs in live-cell imaging and flow cytometry.
• Enzyme Inhibition Studies: Serves as a tool compound for investigating the activity and inhibition profiles of key enzymes in the sphingolipid pathway, such as sphingosine kinases.
• High-Content Screening (HCS): Employed in automated screening platforms to identify modulators of lipid metabolism and related cellular processes in drug discovery campaigns.
• Mechanistic Pharmacology: Facilitates research into the role of sphingolipids in apoptosis, autophagy, and cell proliferation, aiding in target validation.
• Diagnostic Assay Development: Acts as a key component in developing fluorescence-based assays for clinical research and diagnostic applications related to metabolic disorders.

Basic Information

Product Name	C6 Nbd Safingol
CAS No.	114301-97-2
Molecular Formula	C31H45N3O3
Molecular Weight	507.71 g/mol
Synonyms	NBD C6-Safingol; N-[6-[(7-Nitro-2-1,3-benzoxadiazol-4-yl)amino]hexyl]-D-erythro-sphinganine; D-erythro-NBD C6-Sphinganine; (2S,3S)-2-Amino-3-hydroxyoctadecan-1-yl 6-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)hexylcarbamate; Fluorescent Safingol C6; L-threo-NBD C6-Dihydrosphingosine
EINECS	Contact for details

Quality Control

Our C6 Nbd Safingol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	Yellow to orange solid or film
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Solubility	Soluble in DMSO, ethanol, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.