Description

Phorbol 13-Myristate is a potent and specific protein kinase C (PKC) activator widely used in biochemical and pharmacological research. This compound is critical for studying intracellular signal transduction pathways, cellular differentiation, and immune cell activation. It is an essential reagent for researchers and scientists in the pharmaceutical, biotechnology, and academic sectors investigating cancer biology, immunology, and inflammatory diseases.

Application

• Biomedical Research: As a standard PKC activator in cell signaling studies, tumor promotion research, and apoptosis investigations.
• Immunology Studies: Used to stimulate T-cell activation, neutrophil oxidative burst, and cytokine production in vitro.
• Drug Discovery & Screening: Serves as a key pharmacological tool and positive control in high-throughput screening assays for PKC inhibitor development.
• Inflammation Models: Applied in experimental models to induce inflammatory responses and study anti-inflammatory compounds.
• Cell Biology: Used to investigate membrane translocation of PKC isoforms and other downstream signaling events.

Basic Information

Product Name	Phorbol 13-Myristate
CAS No.	115905-51-6
Molecular Formula	C36H56O8
Molecular Weight	616.83 g/mol
Synonyms	PMA; TPA; Phorbol 12-Myristate 13-Acetate (common historical name); Phorbol Myristate Acetate; Tetradecanoylphorbol Acetate; 12-O-Tetradecanoylphorbol-13-acetate; NSC 350836; PKC Activator
EINECS	Contact for details

Quality Control

Our Phorbol 13-Myristate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, identity confirmation by spectroscopic methods (NMR, MS), and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are available upon request to ensure it meets the stringent requirements for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. For long-term storage, desiccate and keep frozen. Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.