Description

Crabp-Ii Ligand 1 is a synthetic retinoid analog designed for high-affinity binding to Cellular Retinoic Acid-Binding Protein II (CRABP-II). This compound matters as a critical research tool for modulating retinoic acid signaling pathways, which are central to cellular differentiation, proliferation, and apoptosis. Researchers in pharmaceutical R&D and academic biochemistry need it for studying cancer therapeutics, dermatological conditions, and developmental biology. Its precise molecular interaction makes it invaluable for target validation and mechanistic studies.

Application

• Biochemical Research: Used as a high-affinity ligand in binding assays and competitive displacement studies to characterize CRABP-II function and inhibition.
• Drug Discovery: Serves as a lead compound or reference standard in the development of novel retinoid-based therapies targeting cancers and skin diseases.
• Mechanistic Studies: Employed to elucidate the role of retinoic acid pathways in cellular differentiation, proliferation, and apoptosis.
• Target Validation: A key tool for validating CRABP-II as a therapeutic target in various disease models, including oncology.
• Academic Research: Utilized in university and institutional labs for fundamental research on nuclear receptor signaling and gene regulation.
• Compound Library Screening: Acts as a reference compound in high-throughput screening (HTS) campaigns to identify new modulators of retinoid signaling.

Basic Information

Product Name	Crabp-Ii Ligand 1
CAS No.	135325-47-2
Molecular Formula	C24H28O2
Molecular Weight	348.48 g/mol
Synonyms	CRABP-II Ligand 1; (2E,4E,6E,8E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid; 4-Methoxy-TMTT; Retinoid analog for CRABP-II; Cellular Retinoic Acid-Binding Protein II Ligand; LG100754 (related analog class); Synthetic Retinoid AM580 (structural analog).
EINECS	Contact for details

Quality Control

Our Crabp-Ii Ligand 1 is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) documenting identity, purity, and assay is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere or with desiccant to maintain stability. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time matches reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 98.0%
Assay	≥ 97.0% (on dried basis)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.