Description

Poly-Dl-Ornithine Hydrobromide is a synthetic polyamino acid derivative of the essential amino acid ornithine, widely utilized in biomedical research and advanced material science. Its primary commercial value lies in its exceptional ability to promote cell adhesion and proliferation on various substrates, making it a critical reagent for in vitro studies. This product is essential for researchers and manufacturers in the biotechnology, pharmaceutical, and diagnostic sectors who require reliable, high-purity substrates for cell culture and surface coating applications.

Application

• Cell Culture Substrate Coating: Used to coat cultureware (e.g., plates, dishes, coverslips) to enhance the attachment and growth of primary cells, neurons, and other difficult-to-culture cell types.
• Neuroscience Research: Serves as a preferred substrate for the cultivation of primary neurons, glial cells, and neural stem cells, facilitating studies in neurodevelopment, neurotoxicity, and regeneration.
• Biomaterial Functionalization: Applied to modify the surface properties of polymers, glass, and other biomaterials to improve biocompatibility and cellular integration for tissue engineering scaffolds.
• Diagnostic Device Manufacturing: Employed in the production of biosensors and diagnostic chips where controlled cell adhesion is required for assay performance.
• Virus and Vector Production: Used as a coating agent in bioreactors and cell factories to maximize adherent cell yield for viral vector and vaccine production processes.
• Stem Cell Research: Provides a defined, synthetic matrix alternative to animal-derived products for the expansion and differentiation of various stem cell lines.

Basic Information

Product Name	Poly-Dl-Ornithine Hydrobromide
CAS No.	82682-33-5
Molecular Formula	(C5H12N2O2 • HBr)n
Molecular Weight	Approx. 30,000 - 70,000 (average MW, varies by grade)
Synonyms	Poly(ornithine hydrobromide); PDL-ORN HBr; DL-Polyornithine Hydrobromide; Polyornithine HBr; Poly-DL-ornithine • HBr; Ornithine Polymer Hydrobromide; NSC 77625; Poly(ornithine) hydrobromide salt
EINECS	Contact for details

Quality Control

Our Poly-Dl-Ornithine Hydrobromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, consistent molecular weight distribution, and optimal biological performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, endotoxin levels, and sterility (where applicable). Our quality commitment aligns with the standards required for research and bioprocessing applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent absorption of atmospheric moisture, which can affect performance.

Specification

Item	Specification
Appearance	White to off-white powder or lyophilized solid
Identification (IR)	Conforms to structure
Assay (Polyornithine base)	≥ 95.0% (by titration)
Molecular Weight (Avg.)	30,000 - 70,000 Da (GPC)
Solubility (in Water)	Clear, colorless solution at 1 mg/mL
pH (1% Solution)	5.0 - 7.0
Endotoxin	< 1.0 EU/mg (for cell culture grade)
Loss on Drying	≤ 5.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.