Description

1,2-Dipalmitoyl-3-Trimethylammonium-Propane (CAS NO 139984-36-4) is a synthetic, cationic phospholipid analog, widely recognized as a key component in advanced lipid nanoparticle (LNP) formulations. Its primary value lies in its ability to form stable, positively charged liposomes and nanoparticles, which are essential for the efficient encapsulation and delivery of sensitive bioactive molecules. This compound is critically needed by pharmaceutical and biotechnology companies engaged in the development of novel drug delivery systems, particularly for nucleic acid therapeutics like mRNA and siRNA, as well as for gene therapy and vaccine applications.

Application

• mRNA Vaccine & Therapeutic Delivery: A critical cationic lipid component in Lipid Nanoparticles (LNPs) for encapsulating and protecting mRNA, enabling its cellular uptake and expression.
• siRNA & Gene Therapy: Used to formulate stable, non-viral vectors for the delivery of small interfering RNA (siRNA) and plasmid DNA to target cells for gene silencing or editing.
• Liposome & Nanocarrier Development: Serves as a structural and functional lipid to create cationic liposomes for the delivery of drugs, proteins, or diagnostic agents.
• Transfection Reagent Formulation: A key ingredient in commercial and research-grade transfection reagents to enhance DNA/RNA delivery into cells in vitro.
• Biomimetic Membrane Research: Used in biophysical studies to model and investigate the properties of cationic membranes and their interactions with biomolecules.
• Adjuvant Systems: Explored in vaccine development for its potential immunostimulatory properties when formulated into particulate delivery systems.

Basic Information

Product Name	1,2-Dipalmitoyl-3-Trimethylammonium-Propane
CAS No.	139984-36-4
Molecular Formula	C41H84NO4P
Molecular Weight	686.09 g/mol
Synonyms	DPTAP; 1,2-Dihexadecanoyl-3-(trimethylammonio)propane; Dipalmitoyl Trimethylammonium Propane; Trimethyl(3-((1,2-bis(hexadecanoyl)oxy)propyl)phosphonium; (2,3-Bis(palmitoyloxy)propyl)trimethylammonium; Cationic Lipid DPTAP; CLinD PTAP; Avanti Polar Lipid 890890
EINECS	Contact for details

Quality Control

Our 1,2-Dipalmitoyl-3-Trimethylammonium-Propane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for pharmaceutical and life science research. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We support compliance with cGMP and ISO guidelines for critical raw materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to maintain stability and prevent degradation. This product is hygroscopic (moisture-sensitive); ensure containers are sealed immediately after use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm
Water Content (KF)	< 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.