Description

n-[1-(2,3-Dioleyloxy)Propyl]-N,N,n-Trimethylammonium Chloride is a high-purity cationic lipid compound, also known as DOTMA chloride. This material is valued for its critical role as a key component in advanced lipid nanoparticle (LNP) formulations for nucleic acid delivery. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing next-generation therapeutics, including mRNA vaccines, gene therapies, and siRNA-based drugs.

Application

• Primary component in cationic lipid nanoparticle (LNP) formulations for drug delivery.
• Critical excipient for the encapsulation and delivery of mRNA in vaccine and therapeutic development.
• Used in non-viral vector systems for gene therapy and gene editing applications (e.g., CRISPR-Cas9).
• Formulation agent for small interfering RNA (siRNA) delivery to target specific genes.
• Key material in liposome and transfection reagent research and production.
• Used in preclinical and clinical-stage development of oncology and rare disease treatments.

Basic Information

Product Name	n-[1-(2,3-Dioleyloxy)Propyl]-N,N,n-Trimethylammonium Chloride
CAS No.	132172-61-3
Molecular Formula	C42H84ClNO2
Molecular Weight	670.58 g/mol
Synonyms	DOTMA Chloride; 1,2-Dioleyloxy-3-(trimethylammonio)propane chloride; N-[1-(2,3-Dioleoyloxy)propyl]-N,N,N-trimethylammonium chloride; DOTMA; 1,2-Di-O-octadecenyl-3-trimethylammonium propane chloride; (2,3-Dioleyloxypropyl)trimethylammonium chloride; CLinDOTMA
EINECS	Contact for details

Quality Control

Our n-[1-(2,3-Dioleyloxy)Propyl]-N,N,n-Trimethylammonium Chloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical research and development. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP guidelines where applicable, and our quality systems are designed to support regulatory filings for advanced therapy medicinal products (ATMPs).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere, please contact us for specific recommendations. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.