Description

Dotap Mesylate is a cationic lipid compound widely recognized for its critical role in the formulation of liposomes and lipid nanoparticles (LNPs). This product is essential for enabling the efficient delivery of nucleic acids, including mRNA and siRNA, into cells for research and therapeutic applications. It is a fundamental reagent for pharmaceutical R&D, biotechnology companies, and academic institutions focused on gene therapy, vaccine development, and advanced drug delivery systems.

Application

• Lipid Nanoparticle (LNP) Formulation: A key cationic lipid component for constructing stable, non-viral vectors for mRNA and siRNA encapsulation and delivery.
• Gene Therapy Research: Used in the development of transfection reagents and lipoplexes for in vitro and in vivo gene delivery studies.
• Vaccine Development: Critical in the formulation of lipid-based delivery systems for novel vaccines, including mRNA-based platforms.
• Drug Delivery Systems: Employed to create targeted liposomal carriers for a variety of therapeutic agents, enhancing cellular uptake and efficacy.
• Biophysical Studies: Utilized in membrane biophysics research to study lipid bilayer interactions, fusion, and structure.
• Diagnostic Agent Carrier: Serves as a component in liposomes designed to carry imaging or contrast agents for diagnostic purposes.

Basic Information

Product Name	Dotap Mesylate
CAS No.	144139-73-1
Molecular Formula	C42H80N2O4 • CH4O3S
Molecular Weight	771.15 g/mol
Synonyms	1,2-Dioleoyl-3-trimethylammonium-propane (chloride salt) methanesulfonate; DOTAP Methanesulfonate; N-[1-(2,3-Dioleoyloxy)propyl]-N,N,N-trimethylammonium methanesulfonate; DOTAP-MS; DOTAP Mesylate Salt; (2,3-Dioleoyloxy-propyl)-trimethylammonium methanesulfonate; TAP Lipid Mesylate; CLinDOTMA Mesylate
EINECS	Contact for details

Quality Control

Our Dotap Mesylate is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP guidelines where required for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to warm to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm
Bacterial Endotoxins	< 10 EU/mg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.