Description

1,2-Bis(Hexadecyloxy)-3-Trimethylaminopropane is a cationic lipid compound featuring a quaternary ammonium head group and long hydrophobic alkyl chains. This structure is critical for its role as a key excipient in the formulation of lipid nanoparticles (LNPs), which are essential for modern nucleic acid delivery systems. It is primarily required by pharmaceutical R&D and manufacturing companies engaged in the development of advanced therapeutics, including mRNA vaccines, gene therapies, and siRNA-based treatments.

Application

• Lipid Nanoparticle (LNP) Formulation: A critical cationic lipid component for encapsulating and delivering mRNA, siRNA, and other nucleic acids.
• Non-Viral Gene Delivery: Used in research and development of non-viral vectors for gene therapy applications.
• Vaccine Development: An essential material in the production of next-generation mRNA-based vaccines.
• Biomedical Research: A tool compound for studying cellular uptake mechanisms and membrane fusion processes.
• Drug Delivery Systems: Incorporated into liposomal and other nanocarrier systems for targeted drug delivery.
• Transfection Reagent Component: Used in the formulation of commercial and research-grade transfection reagents for *in vitro* and *in vivo* studies.

Basic Information

Product Name	1,2-Bis(Hexadecyloxy)-3-Trimethylaminopropane
CAS No.	104872-46-0
Molecular Formula	C41H87NO2
Molecular Weight	626.14 g/mol
Synonyms	1,2-Di-O-hexadecyl-rac-glycero-3-trimethylammonium propane; DLin-MC3-DMA (historical research code); Cationic Lipid MC3; Trimethyl[3-[(1-oxohexadecyl)oxy]-2-[(1-oxohexadecyl)oxy]propyl]ammonium; Heptatriacontanoic acid, 36-(trimethylammonio)-, inner salt; MC3 Lipid; 3-[(Hexadecanoyloxy)-2-(hexadecanoyloxy)propyl] trimethylammonium
EINECS	Contact for details

Quality Control

Our 1,2-Bis(Hexadecyloxy)-3-Trimethylaminopropane is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, essential for sensitive pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP guidelines for advanced therapeutic medicinal products (ATMPs) and relevant ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This material is hygroscopic (moisture-sensitive); ensure containers are sealed immediately after use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.