Description

Dioctadecylamidoglycylspermine is a synthetic, polyamine-based cationic lipid with a high molecular weight. This compound is of significant interest for its ability to form stable complexes with nucleic acids, facilitating their cellular delivery. It is primarily utilized by researchers and developers in the biotechnology and pharmaceutical industries for advanced gene therapy and transfection applications. The product is supplied under the identifier CAS No. 124050-77-7.

Application

• Gene Delivery Vector: A key component in the formulation of non-viral transfection reagents for introducing DNA, RNA, or siRNA into eukaryotic cells.
• Lipid Nanoparticle (LNP) Formulation: Used as a cationic helper lipid to enhance the stability, encapsulation efficiency, and endosomal escape of nucleic acid payloads in LNP systems.
• Biomedical Research: A critical tool for in vitro and in vivo studies requiring efficient and customizable nucleic acid delivery.
• Therapeutic Development: Serves as a building block in the research and pre-clinical development of gene therapies and mRNA-based vaccines.
• Complexation Agent: For the condensation and protection of genetic material from enzymatic degradation prior to cellular uptake.

Basic Information

Product Name	Dioctadecylamidoglycylspermine
CAS No.	124050-77-7
Molecular Formula	C46H98N6O
Molecular Weight	751.3 g/mol
Synonyms	N1,N14-Bis(octadecylcarbamoylmethyl)spermine; DOSPA (common component of Lipofectamine); Dioctadecylamidoglycylspermidine (related name); Cationic lipid 124050-77-7; N,N-Dioctadecylamidoglycylspermine; Gene transfer lipid; Transfection lipid; Lipopolyamine
EINECS	Contact for details

Quality Control

Our Dioctadecylamidoglycylspermine is manufactured under a strict quality management system. Each batch is characterized and tested to ensure identity, purity, and performance consistency suitable for critical research and development applications. Comprehensive Certificates of Analysis (COA) detailing purity, identity confirmation (e.g., by NMR, MS), and functional performance data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Keep the container tightly sealed in a desiccator after opening.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Functional Activity (Transfection)	Reported per COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.