Description

n-[1-(2,3-Dioleyloxy)Propyl]-N,N,n-Trimethylammonium Chloride is a high-purity cationic lipid compound, widely recognized for its critical role in advanced formulation science. Its primary value lies in its ability to form stable, non-toxic complexes with nucleic acids, making it a cornerstone material for modern delivery systems. This product is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly those developing next-generation therapeutics like lipid nanoparticles (LNPs) for mRNA vaccines and gene therapies.

Application

• Lipid Nanoparticle (LNP) Formulation: A key cationic lipid component for encapsulating and delivering mRNA, siRNA, and other nucleic acid payloads.
• Gene Therapy & Transfection Reagents: Used in the development of non-viral vectors for efficient cellular uptake and gene expression in vitro and in vivo.
• Vaccine Development: Critical for formulating stable and immunogenic mRNA-based vaccine candidates.
• Liposome & Nanocarrier Systems: Serves as a structural and functional lipid to create positively charged vesicles for targeted drug delivery.
• Biochemical Research: Employed in academic and industrial R&D for studying membrane interactions, cellular delivery mechanisms, and novel therapeutic platforms.
• Cosmetic & Dermatological Actives Delivery: Facilitates the enhanced skin penetration and stability of active ingredients in advanced cosmetic formulations.

Basic Information

Product Name	n-[1-(2,3-Dioleyloxy)Propyl]-N,N,n-Trimethylammonium Chloride
CAS No.	122342-03-4
Molecular Formula	C45H88ClNO2
Molecular Weight	710.66 g/mol
Synonyms	DOTMA Chloride; 1,2-Dioleyloxy-3-(trimethylammonio)propane chloride; N-[1-(2,3-Dioleoyloxy)propyl]-N,N,N-trimethylammonium chloride; DOTMA; DLIN-MC3-DMA (related analog); Cationic lipid 1; CL-1; Trimethyl[2,3-bis[(9Z)-9-octadecen-1-yloxy]propyl]ammonium chloride
EINECS	Contact for details

Quality Control

Our n-[1-(2,3-Dioleyloxy)Propyl]-N,N,n-Trimethylammonium Chloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive pharmaceutical applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to support regulatory filings for advanced therapy medicinal products (ATMPs).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the certificate of analysis. For long-term storage under inert atmosphere, please contact us for specific recommendations. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.