Description

Cholesterylphosphorylethylpyridinium is a specialized cationic lipid derivative that combines a cholesterol backbone with a pyridinium head group. This unique molecular structure is critical for its role as a key functional component in advanced drug delivery systems, particularly for nucleic acid therapeutics. It is essential for research and development teams in the pharmaceutical and biotechnology sectors who require high-purity, reliable materials for formulating next-generation lipid nanoparticles (LNPs) and liposomes.

Application

• Lipid Nanoparticle (LNP) Formulation: A critical cationic lipid component for the encapsulation and delivery of mRNA, siRNA, and other nucleic acids in therapeutic applications.
• Gene Therapy Research: Used in the development of non-viral vectors for targeted gene delivery and transfection studies in vitro and in vivo.
• Liposome Production: Serves as a structural and functional lipid to create stable, cationic liposomes for drug and vaccine delivery platforms.
• Biomembrane Studies: Employed as a model compound in biophysical research to study membrane interactions, fusion, and cellular uptake mechanisms.
• Diagnostic Agent Carrier: Potential use in formulating carriers for contrast agents or other diagnostic molecules in imaging technologies.

Basic Information

Product Name	Cholesterylphosphorylethylpyridinium
CAS No.	143693-01-0
Molecular Formula	C34H55NO4P
Molecular Weight	572.78 g/mol
Synonyms	Cholesterylphosphorylethylpyridinium bromide; 1-(2-((3S,8S,9S,10R,13R,14S,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)-2-oxoethyl)pyridin-1-ium-1-yl phosphate; Chol-Py; Cationic cholesterol derivative; Pyridinium, 1-[2-[[(3β)-cholest-5-en-3-yl]oxy]-2-oxoethyl]-, phosphate (1:1)
EINECS	Contact for details

Quality Control

Our Cholesterylphosphorylethylpyridinium is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive pharmaceutical research. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant GMP guidelines for advanced pharmaceutical intermediates, and specifications can be aligned with client-specific requirements for critical application projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.