Description

1,2-Dioleoyl-Sn-Glycero-3-Phosphoethanolamine-n-(Succinyl) (Sodium Salt) is a functionalized phospholipid derivative, specifically a succinylated phosphatidylethanolamine (PE) conjugated with oleic acid chains. This compound matters for its unique amphiphilic structure and reactive succinyl group, which enables advanced formulation capabilities and covalent conjugation strategies in cutting-edge research and development. It is primarily needed by pharmaceutical, biotechnology, and advanced material science industries for applications in drug delivery systems, liposomal formulations, and surface functionalization.

Application

• Liposome and Lipid Nanoparticle (LNP) Formulation: A key functional lipid component for constructing pH-sensitive or targeted drug delivery carriers, particularly for mRNA, siRNA, and other nucleic acid therapeutics.
• Surface Modification and Bioconjugation: The reactive succinyl group allows for covalent attachment to amines on proteins, peptides, or other biomolecules, facilitating the creation of functionalized membranes or solid supports.
• Biomimetic Membrane Research: Used in the construction of model cell membranes to study membrane-protein interactions, fusion processes, and signaling events.
• Diagnostic Reagent Preparation: Serves as a starting material or intermediate for synthesizing fluorescent or other tagged phospholipid probes used in imaging and assays.
• Stabilizer for Emulsions and Dispersions: Acts as an advanced emulsifier or stabilizer in high-value cosmetic and dermatological formulations requiring specific interfacial properties.
• Material Science and Nanotechnology: Employed in the bottom-up synthesis of functional nanomaterials and coatings with tailored surface chemistry.

Basic Information

Product Name	1,2-Dioleoyl-Sn-Glycero-3-Phosphoethanolamine-n-(Succinyl) (Sodium Salt)
CAS No.	111613-33-3
Molecular Formula	C45H81NNaO10P
Molecular Weight	858.09 g/mol
Synonyms	18:1 (δ9-Cis) PE (Succinyl); DOPE-succinyl (sodium salt); 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine-N-succinate (sodium salt); Succinyl-DOPE; N-Succinyl-1,2-dioleoyl-sn-glycero-3-phosphoethanolamine sodium salt; N-(Succinyl)-1,2-dioleoylphosphatidylethanolamine sodium salt; (2R)-2,3-Bis[[(Z)-octadec-9-enoyl]oxy]propyl (2-succinamidoethyl) phosphate sodium salt
EINECS	Contact for details

Quality Control

Our high-purity phospholipids are manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided, detailing results from key tests such as Identity (IR, NMR), Purity (HPLC), and related substance profiles. We support development and cGMP-grade requirements for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and hydrolysis. This product is hygroscopic (moisture-sensitive) and easily oxidized; allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white waxy solid or film
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Solvent Residue (GC)	Meets ICH guidelines
Water Content (KF)	≤ 2.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.