Description

Dotap CAS NO 144189-73-1 is a cationic lipid compound widely recognized for its critical role in the formulation of liposomes and lipid nanoparticles (LNPs). This material is essential for enabling the efficient delivery of nucleic acids, such as DNA and RNA, into cells for research and therapeutic applications. It is a fundamental component for pharmaceutical developers, biotechnology researchers, and CROs working on gene therapy, mRNA vaccines, and advanced drug delivery systems.

Application

• Lipid Nanoparticle (LNP) Formulation: A key cationic lipid component for encapsulating and delivering mRNA, siRNA, and other nucleic acid therapeutics.
• Gene Transfection Reagent: Used to form lipoplexes for the efficient transfection of DNA into various cell lines in vitro and in vivo.
• Non-Viral Vector Development: Serves as a critical building block in the design of novel non-viral vectors for gene therapy applications.
• Research & Development: Essential for academic and industrial R&D focused on understanding and optimizing nucleic acid delivery mechanisms.
• Drug Delivery System Optimization: Employed in the development of targeted delivery systems to improve therapeutic efficacy and reduce off-target effects.

Basic Information

Product Name	Dotap
CAS No.	144189-73-1
Molecular Formula	C42H80ClNO4
Molecular Weight	698.55 g/mol
Synonyms	DOTAP; 1,2-Dioleoyl-3-trimethylammonium-propane (chloride salt); N-[1-(2,3-Dioleoyloxy)propyl]-N,N,N-trimethylammonium chloride; DOTAP Chloride; CL-1; TAP Lipid; Cationic lipid DOTAP; DOTAP (chloride)
EINECS	Contact for details

Quality Control

Our Dotap is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive pharmaceutical and research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and specifications can be aligned with customer-specific requirements for advanced therapeutic development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to warm to room temperature before opening to minimize moisture condensation. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white waxy solid or powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.