Description

1,2-Dipalmitoylphosphatidylethanolamidospermine is a synthetic, cationic lipid derivative designed for advanced biomedical and research applications. Its molecular structure is engineered to facilitate efficient cellular delivery and complexation with nucleic acids. This compound is primarily utilized by researchers and formulators in the pharmaceutical and biotechnology sectors for developing next-generation therapeutic delivery systems.

Application

• Lipid Nanoparticle (LNP) Formulation: A key cationic lipid component for the encapsulation and delivery of mRNA, siRNA, and other genetic materials in therapeutic and vaccine development.
• Gene Therapy Research: Used in non-viral vector systems for in vitro and in vivo transfection studies to introduce genetic material into cells.
• Drug Delivery Systems: Serves as a functional excipient to enhance the cellular uptake and endosomal escape of various therapeutic cargoes.
• Bioconjugation & Probe Development: Acts as a building block for creating fluorescent or tagged lipid probes for membrane and cellular trafficking studies.
• Biomimetic Membrane Studies: Used in the preparation of model membranes to study lipid-protein interactions and membrane dynamics.

Basic Information

Product Name	1,2-Dipalmitoylphosphatidylethanolamidospermine
CAS No.	124076-29-5
Molecular Formula	C45H94N5O8P
Molecular Weight	888.23 g/mol
Synonyms	DPPE-Amidospermine; 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamido-N-spermine; N-Spermine-1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamide; Cationic Lipid 124076-29-5; DPPE-Spermine conjugate; 1,2-Dihexadecanoyl-sn-glycero-3-phosphoethanolamidospermine; DPPE-Amido-Spm; Spermine-derivatized DPPE
EINECS	Contact for details

Quality Control

Our 1,2-Dipalmitoylphosphatidylethanolamidospermine is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for research and formulation use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key specifications such as assay purity, related substances, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) due to its hygroscopic and potentially oxidizable nature. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. For long-term storage, desiccants are recommended.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Main peak retention time matches reference
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.