Description

n-Formyl-Met-Leu-Phe Benzylamide is a synthetic tripeptide derivative, specifically a formylated chemotactic peptide, widely used as a potent and selective agonist for the formyl peptide receptor (FPR). This compound is a critical research tool for studying neutrophil chemotaxis, inflammation, and immune response signaling pathways. It is essential for researchers and manufacturers in the fields of immunology, pharmacology, and drug discovery who require high-purity biochemical reagents for in vitro and in vivo studies.

Application

• Biochemical Research: As a standard agonist for investigating formyl peptide receptor (FPR) activation, downstream signaling, and calcium mobilization in leukocytes.
• Immunology Studies: Used to induce and study neutrophil chemotaxis, superoxide anion production, and degranulation in models of acute inflammation.
• Drug Discovery & Screening: Serves as a reference compound and positive control in high-throughput screening (HTS) assays to identify novel FPR antagonists or modulators.
• Pharmacological Profiling: Employed in vitro to characterize the potency and efficacy of experimental compounds targeting inflammatory pathways.
• Cell Biology: A tool for studying receptor-ligand interactions, G-protein coupled receptor (GPCR) function, and cell migration mechanisms.
• Standard Reference Material: Used for the calibration of assays and validation of experimental models related to innate immunity and inflammation.

Basic Information

Product Name	n-Formyl-Met-Leu-Phe Benzylamide
CAS No.	80180-62-7
Molecular Formula	C29H39N5O5S
Molecular Weight	569.71 g/mol
Synonyms	fMLP Benzylamide; N-Formylmethionyl-leucyl-phenylalanine benzylamide; For-Met-Leu-Phe-NH-Benzyl; Formyl-Met-Leu-Phe-Benzylamide; Chemotactic Peptide fMLP-Benzylamide; fMLP-Bzl; fMLP-NH-Bzl; Formyl Peptide Receptor Agonist
EINECS	Contact for details

Quality Control

Our n-Formyl-Met-Leu-Phe Benzylamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.