Description

1,2-Dimyristoyl-3-Dimethylammonium-Propane is a synthetic cationic lipid, widely recognized for its role as a key component in advanced lipid nanoparticle (LNP) formulations. This compound is essential for creating stable, positively charged delivery systems that facilitate the efficient encapsulation and cellular uptake of sensitive biomolecules. It is a critical material for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for the development of novel gene therapies, mRNA vaccines, and other nucleic acid delivery platforms.

Application

• Primary Component in Lipid Nanoparticles (LNPs): Serves as a cationic helper lipid in LNP formulations for the delivery of mRNA, siRNA, and DNA.
• Gene Therapy & Vaccine Development: Critical for formulating non-viral vectors in cutting-edge therapeutic and prophylactic applications.
• Transfection Reagent Formulation: Used in the development of high-efficiency reagents for in vitro and in vivo transfection studies.
• Drug Delivery Systems: Enables the targeted delivery of other therapeutic agents by forming stable, biocompatible carrier complexes.
• Biomaterials & Nanomedicine Research: A fundamental building block for academic and industrial research into novel nanocarriers.
• Liposome Preparation: Used to create cationic liposomes for various diagnostic and therapeutic purposes.

Basic Information

Product Name	1,2-Dimyristoyl-3-Dimethylammonium-Propane
CAS No.	72719-84-7
Molecular Formula	C33H66NO4+
Molecular Weight	540.89 g/mol
Synonyms	DMDAP; DLin-MC3-DMA (common analog reference); 1,2-Ditetradecanoyl-3-(trimethylammonio)propane; 3-(Dimethylamino)propane-1,2-diyl didodecanoate (cationic form); Cationic Lipid MC3; DMTAP; DMPC analog (cationic); DLin-MC3-DMA precursor lipid
EINECS	Contact for details

Quality Control

Our 1,2-Dimyristoyl-3-Dimethylammonium-Propane is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical and research applications. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to support regulatory filings for GMP-grade material upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a controlled, dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.