Description

12-o-Tetradeca-2,4,6,8-Tetranoylphorbol-13-Acetate is a potent and specific protein kinase C (PKC) activator derived from the phorbol ester family. This compound is a critical research tool for studying signal transduction pathways, cellular proliferation, and tumor promotion mechanisms in vitro. It is primarily utilized by researchers and scientists in the fields of biochemistry, oncology, and pharmacology for advanced cell biology studies and drug discovery programs.

Application

• Biochemical Research: A standard activator for studying Protein Kinase C (PKC) isoforms and their role in intracellular signaling cascades.
• Oncology Studies: Used to investigate tumor promotion mechanisms and the molecular basis of carcinogenesis in cell culture models.
• Cell Biology: Employed to induce cellular differentiation, proliferation, or apoptosis in various cell lines to understand regulatory pathways.
• Drug Discovery & Screening: Serves as a positive control or a challenge agent in high-throughput screens for identifying novel PKC inhibitors or modulators.
• Pharmacology: Used to elucidate the physiological and pathological functions of PKC in neurological, cardiovascular, and inflammatory processes.
• Academic & Institutional Research: Essential reagent for universities and research institutes conducting fundamental research in molecular and cellular biology.

Basic Information

Product Name	12-o-Tetradeca-2,4,6,8-Tetranoylphorbol-13-Acetate
CAS No.	64604-09-7
Molecular Formula	C36H56O8
Molecular Weight	616.83 g/mol
Synonyms	12-O-Tetradecanoylphorbol-13-acetate (TPA); Phorbol 12-myristate 13-acetate (PMA); Tetradecanoylphorbol Acetate; NSC 668257; 4α-Phorbol 12-myristate 13-acetate; TPA/PMA; Phorbol Ester TPA; Tumor Promoter TPA
EINECS	Contact for details

Quality Control

Our 12-o-Tetradeca-2,4,6,8-Tetranoylphorbol-13-Acetate is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. Due to its hygroscopic nature, the container should be allowed to reach room temperature before opening to prevent condensation and moisture uptake. For long-term stability, store under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Solubility	Soluble in DMSO, ethanol, acetone; insoluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.