Description

Phorbolol Myristate Acetate is a potent and specific protein kinase C (PKC) activator widely used in biochemical and pharmacological research. This compound is critical for studying intracellular signal transduction pathways, cellular differentiation, and tumor promotion mechanisms. It is an essential reagent for researchers in pharmaceutical development, oncology, and immunology, particularly for in vitro cell stimulation studies.

Application

• Biochemical Research: A standard tool for activating Protein Kinase C (PKC) isoforms in cell-free and cellular assays to study downstream signaling events.
• Immunology Studies: Used to stimulate neutrophil oxidative burst, degranulation, and cytokine production in immune cell models.
• Oncology Research: Employed to investigate the role of PKC in tumor promotion, cell proliferation, and apoptosis.
• Neuroscience: Applied in studies of neurotransmitter release, synaptic plasticity, and neuronal differentiation mediated by PKC.
• Drug Discovery: Serves as a positive control and a challenge agent in high-throughput screening for PKC inhibitor development.
• Cell Biology: Utilized to induce differentiation in various cell lines, including leukemia and epithelial cells.

Basic Information

Product Name	Phorbolol Myristate Acetate
CAS No.	56937-68-9
Molecular Formula	C36H56O8
Molecular Weight	616.83 g/mol
Synonyms	PMA; Phorbol 12-Myristate 13-Acetate; TPA; Tetradecanoylphorbol Acetate; 12-O-Tetradecanoylphorbol-13-acetate; NSC 350836; Phorbol Myristate Acetate; 4α-Phorbol 12-myristate 13-acetate
EINECS	Contact for details

Quality Control

Our Phorbolol Myristate Acetate is produced and tested under strict quality management systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, residual solvents, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. The product is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, keep desiccated at the recommended temperature.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.