Description

Salubrinal is a selective inhibitor of eIF2α dephosphorylation, a key compound for modulating the integrated stress response (ISR) pathway in cellular research. This small molecule is valued for its ability to protect cells from endoplasmic reticulum (ER) stress-induced apoptosis, making it a critical tool for studying protein homeostasis, neurodegeneration, and viral replication. It is primarily utilized by researchers and developers in the fields of academic research, pharmaceutical R&D, and biotechnology for investigating disease mechanisms and potential therapeutic interventions.

Application

• Biomedical Research: A fundamental tool for studying the unfolded protein response (UPR) and ER stress signaling pathways in cell culture models.
• Neurodegenerative Disease Studies: Used to investigate protective mechanisms against apoptosis in models of diseases like Alzheimer's, Parkinson's, and prion disorders.
• Virology Research: Employed to explore how viral infections manipulate host cell stress responses for replication and survival.
• Cardioprotection Research: Applied in studies aiming to understand and mitigate cellular damage following ischemic events like heart attacks.
• Oncology Research: Utilized to examine the role of cellular stress in cancer cell survival, drug resistance, and tumor progression.
• Drug Discovery Screening: Serves as a reference compound or positive control in high-throughput screens for novel ISR modulators.

Basic Information

Product Name	Salubrinal
CAS No.	405060-95-9
Molecular Formula	C₂₁H₁₇ClN₂O₅S
Molecular Weight	444.89 g/mol
Synonyms	Salubrinal; 1-Phenyl-3-(2-thienyl)-1H-pyrazole-5-carboxylic acid 2-(1,3-thiazolidin-2-ylidene)hydrazide; N-(3-Phenyl-1H-pyrazol-5-yl)-2-(thiazolidin-2-ylidene)hydrazinecarbothioamide; BML-PR130; eIF2α Dephosphorylation Inhibitor; ER Stress Inhibitor
EINECS	Contact for details

Quality Control

Our Salubrinal is produced under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption, which may affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.