Description

4-Hydroxysphinganine-1-Phosphate (Saccharomyces Cerevisiae) is a phosphorylated sphingoid base, a key bioactive lipid metabolite derived from yeast. This compound is crucial for research into sphingolipid signaling pathways, which regulate critical cellular processes like apoptosis, proliferation, and stress responses. It is an essential reference standard and biochemical tool for pharmaceutical R&D, academic research, and biotechnology companies focused on metabolic studies, drug discovery, and understanding cellular mechanisms.

Application

• Biochemical Research: As a critical intermediate in the study of sphingolipid metabolism and the de novo synthesis pathway.
• Pharmaceutical Development: Used as a reference standard in drug discovery programs targeting enzymes like sphingosine kinases or ceramide synthases.
• Cell Signaling Studies: Investigating its role as a bioactive lipid mediator in apoptosis, cell growth, and response to environmental stress.
• Metabolomics & Lipidomics: Serves as a high-purity analytical standard for LC-MS or HPLC-based quantification in complex biological samples.
• Enzyme Assay Substrate: For in vitro studies to characterize the activity and inhibition of specific lipid kinases and phosphatases.
• Academic Research: Fundamental tool for universities and research institutes exploring yeast biology and conserved eukaryotic signaling pathways.

Basic Information

Product Name	4-Hydroxysphinganine-1-Phosphate (Saccharomyces Cerevisiae)
CAS No.	383908-62-1
Molecular Formula	C18H40NO6P
Molecular Weight	397.49 g/mol
Synonyms	Phytosphingosine-1-Phosphate (from S. cerevisiae); PHS-1-P; 4-Hydroxysphinganine 1-Phosphate; D-erythro-Phytosphingosine-1-phosphate; (2S,3S,4R)-2-Amino-3,4-dihydroxyoctadecyl dihydrogen phosphate; Long Chain Base Phosphate; Yeast Phytosphingosine Phosphate; LCB-P
EINECS	Contact for details

Quality Control

Our 4-Hydroxysphinganine-1-Phosphate is produced and handled under strict quality protocols suitable for research applications. Each batch is analyzed to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, identification, and impurity profiles are provided to guarantee consistency and reliability for your critical research. We support compliance with relevant standards for biochemical and analytical reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in methanol, DMSO; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.