Description

L-α-Phosphatidylinositol-4,5-Bisphosphate (Brain, Porcine) (Ammonium Salt) is a high-purity, natural phospholipid derivative essential for cellular signaling research. This compound serves as a critical substrate and signaling molecule in the study of phosphoinositide pathways, membrane dynamics, and receptor-mediated signal transduction. It is primarily utilized by researchers and manufacturers in the life sciences, pharmaceutical development, and biochemical reagent sectors for advanced in vitro studies.

Application

• Biochemical Research: As a key substrate for enzymes like phospholipase C (PLC) and phosphoinositide 3-kinases (PI3Ks) in signal transduction studies.
• Lipidomics & Cell Biology: For investigating the role of phosphoinositides in membrane trafficking, cytoskeletal reorganization, and cellular compartment identity.
• Drug Discovery & Screening: Used in high-throughput assays to identify and characterize modulators of phosphoinositide-metabolizing enzymes, a target class for various diseases.
• Liposome & Model Membrane Preparation: Incorporated into lipid bilayers to study protein-lipid interactions and membrane domain formation.
• Neuroscience Research: Critical for studying synaptic transmission, neuronal plasticity, and receptor signaling pathways where PIP2 plays a fundamental role.
• Reference Standard: Serves as an analytical standard for mass spectrometry, chromatography, and other techniques in lipid analysis.

Basic Information

Product Name	L-α-Phosphatidylinositol-4,5-Bisphosphate (Brain, Porcine) (Ammonium Salt)
CAS No.	383907-42-4
Molecular Formula	C47H88O19P3 • xC4H12N (Ammonium salt of a variable mixture)
Molecular Weight	~1100 g/mol (Base, variable)
Synonyms	PIP2; PI(4,5)P2; Phosphatidylinositol 4,5-bisphosphate; 1,2-Diacyl-sn-glycero-3-phospho-(1-D-myo-inositol-4,5-bisphosphate); PtdIns(4,5)P2; Brain Phosphoinositides; Phosphoinositol Diphosphate; L-α-Phosphatidylinositol-4,5-diphosphate
EINECS	Contact for details

Quality Control

Our L-α-Phosphatidylinositol-4,5-Bisphosphate is produced and handled under strict quality protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot is characterized using advanced analytical techniques, including HPLC and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing specific test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and easily oxidized; allow the vial to reach room temperature in a desiccator before opening to minimize exposure to moisture and air.

Specification

Item	Specification
Appearance	White to off-white powder or film
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95% (Area %)
Solubility	Soluble in chloroform/methanol/water mixtures
Loss on Drying	≤ 5.0 %
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.