Description

2,2-Dichloro-2-Fluoroacetonitrile is a versatile and highly reactive halogenated acetonitrile derivative. This compound serves as a critical fluorinated building block in advanced organic synthesis, enabling the introduction of the difluoromethylene (CF2) group. It is primarily sought after by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules, including active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: Key synthon for the synthesis of fluorinated heterocycles and bioactive molecules, leveraging the CF2 group to modulate metabolic stability and lipophilicity.
• Agrochemical Synthesis: Building block for creating novel fluorinated pesticides and herbicides, where fluorine substitution enhances biological activity and environmental persistence.
• Material Science Precursor: Used in the development of fluorinated polymers, liquid crystals, and electronic chemicals with unique surface properties and stability.
• Organic Synthesis Reagent: Employed in nucleophilic substitution and cyclization reactions to introduce the valuable gem-dichlorofluoroacetonitrile moiety.
• Research & Development: Essential tool compound in medicinal chemistry and process chemistry for exploring new fluorination strategies and reaction pathways.

Basic Information

Product Name	2,2-Dichloro-2-Fluoroacetonitrile
CAS No.	353-82-2
Molecular Formula	C2Cl2FN
Molecular Weight	127.93 g/mol
Synonyms	Dichlorofluoroacetonitrile; Fluorodichloroacetonitrile; 2-Fluoro-2,2-dichloroacetonitrile; Acetonitrile, 2,2-dichloro-2-fluoro-; Dichloro(fluoro)acetonitrile; FC(Cl2)CN; α,α-Dichloro-α-fluoroacetonitrile
EINECS	Contact for details

Quality Control

Every batch of 2,2-Dichloro-2-Fluoroacetonitrile is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure consistent purity and reliable performance for your synthetic applications. Certificates of Analysis (COA) with detailed specifications from GC, HPLC, and NMR are available upon request to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile nature, store in a cool, well-ventilated place, ideally at 2-8°C. Keep away from strong bases and incompatible materials. Containers should be kept tightly sealed and upright to prevent leakage and moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.