Description

2,6-Difluorobenzonitrile is a high-purity fluorinated aromatic nitrile building block of significant importance in advanced organic synthesis. Its unique substitution pattern makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is essential for R&D and production in the pharmaceutical, agrochemical, and specialty materials sectors, where it serves as a precursor to active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, anti-cancer agents, and other biologically active heterocycles.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and pesticides, where the difluoro motif enhances metabolic stability and bioavailability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorine-containing compounds used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modification: Employed to introduce fluorine atoms into polymer backbones or side chains, improving chemical resistance, thermal stability, and surface properties.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig) to create complex biaryl systems for material science and drug discovery.
• Fluorine Chemistry Research: A valuable reagent in academic and industrial R&D for exploring new fluorination methodologies and creating novel fluorinated scaffolds.

Basic Information

Product Name	2,6-Difluorobenzonitrile
CAS No.	1897-52-5
Molecular Formula	C7H3F2N
Molecular Weight	139.10 g/mol
Synonyms	2,6-Difluorobenzene carbonitrile; 2,6-Difluorophenyl cyanide; Benzonitrile, 2,6-difluoro-; 2,6-DFBN; 2,6-Difluorobenzonitrile; 2,6-Difluorobenzyl nitrile (common misnomer); 2,6-Difluorophenyl nitrile
EINECS	217-581-5

Quality Control

Our 2,6-Difluorobenzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure it meets the highest standards of purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with each shipment. We support compliance with global regulatory frameworks including REACH.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	48 - 52 °C
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.