Description

3-Trifluoromethyl-4-Bromobenzonitrile is a high-value, multi-functional aromatic intermediate featuring both bromine and trifluoromethyl substituents on a benzonitrile core. This compound is critical for introducing lipophilicity and metabolic stability into target molecules, making it a sought-after building block in advanced chemical synthesis. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of specialty chemicals for electronic displays and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to construct complex biaryl systems.
• Fluorine Chemistry Research: An important compound for studying the effects of fluorine substitution on molecular properties in medicinal and materials chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up processes.

Basic Information

Product Name	3-Trifluoromethyl-4-Bromobenzonitrile
CAS No.	1735-53-1
Molecular Formula	C8H3BrF3N
Molecular Weight	250.02 g/mol
Synonyms	4-Bromo-3-(trifluoromethyl)benzonitrile; 4-Bromo-α,α,α-trifluoro-m-toluonitrile; 3-Trifluoromethyl-4-bromobenzonitrile; 4-Bromo-3-trifluoromethylbenzonitrile; 2-Bromo-5-cyanobenzotrifluoride; m-Trifluoromethyl-p-bromobenzonitrile; 1735-53-1; 4-Bromo-α,α,α-trifluoro-3-methylbenzonitrile
EINECS	217-075-8

Quality Control

Every batch of 3-Trifluoromethyl-4-Bromobenzonitrile is manufactured under a strict quality management system and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications such as assay (HPLC), identity (IR, NMR), and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical R&D and production workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.