Description

2,5-Difluoro-1,4-Benzenedicarbonitrile is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms and cyano groups, which are key for modulating electronic properties, lipophilicity, and metabolic stability in target molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics where fluorine substitution is desirable.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides, leveraging the fluorine atoms to enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a core building block for fluorinated liquid crystals and electron-transport/hole-blocking layers in organic light-emitting diodes (OLEDs) due to its electron-deficient character.
• Polymer & Monomer Production: Employed in the creation of specialty polymers, such as polyimides or polyamides, with enhanced thermal stability, chemical resistance, and specific dielectric properties.
• Organic Semiconductor Research: Acts as a key component in n-type organic semiconductors and non-fullerene acceptors for organic photovoltaics (OPVs).
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to construct complex, multifunctional aromatic systems.

Basic Information

Product Name	2,5-Difluoro-1,4-Benzenedicarbonitrile
CAS No.	1897-49-0
Molecular Formula	C8H2F2N2
Molecular Weight	164.11 g/mol
Synonyms	2,5-Difluoroterephthalonitrile; 1,4-Dicyano-2,5-difluorobenzene; 2,5-Difluorobenzene-1,4-dicarbonitrile; Terephthalonitrile, 2,5-difluoro-; 2,5-Difluoro-1,4-dicyanobenzene; 2,5-Difluorobenzenedicarbonitrile; 2,5-DFBN; 2,5-Difluoroterephthalodinitrile
EINECS	217-590-8

Quality Control

Our 2,5-Difluoro-1,4-Benzenedicarbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR, to ensure it meets exacting standards for research and scale-up. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.