Description

2-Amino-4-Trifluoromethylbenzonitrile is a high-value, multi-functional aromatic nitrile building block characterized by its amino and trifluoromethyl substituents. This compound is essential for the synthesis of advanced pharmaceutical intermediates and agrochemicals, where its unique structure imparts desirable biological activity and metabolic stability. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and bioactivity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and advanced polymers with specific electronic or optical properties.
• Fluorinated Compound Library: A valuable scaffold for medicinal chemistry and combinatorial chemistry to build libraries of fluorinated compounds for high-throughput screening.

Basic Information

Product Name	2-Amino-4-Trifluoromethylbenzonitrile
CAS No.	1483-54-1
Molecular Formula	C8H5F3N2
Molecular Weight	186.14 g/mol
Synonyms	2-Amino-α,α,α-trifluoro-p-tolunitrile; 2-Amino-4-(trifluoromethyl)benzonitrile; 4-Cyano-3-(trifluoromethyl)aniline; 2-Amino-α,α,α-trifluoro-4-methylbenzonitrile; Benzonitrile, 2-amino-4-(trifluoromethyl)-; 3-Amino-4-cyanobenzotrifluoride
EINECS	Contact for details

Quality Control

Our 2-Amino-4-Trifluoromethylbenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound may be light-sensitive and should be handled under an inert atmosphere for long-term storage to prevent oxidation. Keep away from strong acids, strong bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.