Description

Tyrosine Protein Kinase Jak 2 (Phospho-Tyr8, 9) is a high-purity, phosphorylated peptide sequence used as a critical biochemical tool in signal transduction research. This compound is essential for studying the activation mechanisms and downstream signaling pathways of the JAK2 kinase, a key target in oncology and immunology. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and diagnostic developers for kinase activity assays, antibody validation, and as a reference standard in quantitative phosphoproteomics.

Application

• Biochemical Research: Used as a specific substrate in in vitro kinase assays to measure JAK2 activity and screen for potential inhibitors.
• Antibody Development & Validation: Serves as a critical positive control antigen for testing the specificity of anti-phospho-JAK2 (Tyr8,9) antibodies in ELISA, Western blot, and immunohistochemistry.
• Cell Signaling Pathway Analysis: Employed in competitive binding studies and as a standard to quantify endogenous phospho-JAK2 levels in cell lysates.
• Drug Discovery & Development: A vital tool in high-throughput screening (HTS) campaigns and mechanistic studies for oncology and autoimmune disease therapeutics.
• Diagnostic Assay Calibration: Used to calibrate and standardize phospho-specific diagnostic kits for clinical research applications.

Basic Information

Item	Details
Product Name	Tyrosine Protein Kinase Jak 2 (Phospho-Tyr8, 9)
CAS No.	247171-44-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	JAK2 (Phospho-Tyr8, 9) Peptide; Phosphorylated JAK2 (Tyr8, Tyr9) Substrate; p-JAK2 (Tyr8/9); Janus Kinase 2 Phosphopeptide (pTyr8, pTyr9); Tyrosine-Protein Kinase JAK2 Phosphorylated Peptide; JAK2 Activation Loop Phosphopeptide; Signal Transducer Phospho-JAK2 Peptide; JAK2 pTyr8/pTyr9 Synthetic Peptide
EINECS	Contact for details

Quality Control

Every batch of our Tyrosine Protein Kinase Jak 2 (Phospho-Tyr8, 9) is manufactured and tested under stringent quality management systems. We guarantee high purity and batch-to-batch consistency through rigorous analytical techniques including HPLC and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and phospho-specificity is provided with each shipment to ensure it meets the exacting standards required for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be kept desiccated. Aliquot upon receipt to avoid repeated freeze-thaw cycles and minimize exposure to ambient conditions.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70%
Phosphorylation Specificity	Confirmed by MS/MS
Solubility	Soluble in aqueous buffers or DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.