Description

Pyr6 CAS NO 245747-08-4 is a potent and selective inhibitor of the transient receptor potential canonical 6 (TRPC6) calcium channel. This compound is a critical research tool for investigating calcium signaling pathways and their role in various physiological and pathological processes. It is primarily utilized by researchers and developers in the fields of pharmacology, neuroscience, and cardiovascular disease research to study cellular mechanisms and validate novel therapeutic targets.

Application

• Biomedical Research: Fundamental research tool for studying TRPC6 channel function and calcium influx in cellular models.
• Cardiovascular Disease Studies: Investigation of TRPC6's role in cardiac hypertrophy, pulmonary arterial hypertension, and renal diseases.
• Neuroscientific Research: Exploration of neuronal signaling, synaptic plasticity, and neurodegenerative conditions where TRPC6 channels are implicated.
• Pharmacological Screening: Used as a reference standard in high-throughput screening assays to identify and characterize new TRPC6 modulators.
• Target Validation: Essential for in vitro and ex vivo studies to validate TRPC6 as a therapeutic target for drug discovery programs.

Basic Information

Product Name	Pyr6
CAS No.	245747-08-4
Molecular Formula	C₂₀H₁₇N₃O₃
Molecular Weight	347.37 g/mol
Synonyms	Pyr6; 2-[(4-Methylphenyl)methyl]-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine-5,6-dione; TRPC6 Inhibitor Pyr6; 2-[(4-Methylphenyl)methyl]-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine-5,6-dione; 245747-08-4; Pyr 6; 2-[(4-Methylbenzyl)-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine-5,6-dione
EINECS	Contact for details

Quality Control

Our Pyr6 is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. For long-term storage, keep desiccated under an inert atmosphere. Allow the product to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.