Description

Rp-8-Bromo-Cyclic GMPS (Sodium Salt) is a chemically modified nucleotide analog, specifically a brominated derivative of cyclic guanosine monophosphate. This compound is a critical research-grade biochemical tool used to study and modulate intracellular signaling pathways, particularly those involving cyclic nucleotide-gated ion channels and protein kinases. It is essential for researchers and developers in pharmaceutical discovery, biochemical assay development, and cell biology research who require high-purity, well-characterized tools for probing complex biological mechanisms.

Application

• Biochemical Research: As a potent and selective activator or inhibitor in studies of cyclic nucleotide-dependent signaling cascades.
• Pharmaceutical Screening: Used in high-throughput screening (HTS) assays to identify novel drug candidates targeting cGMP-related pathways.
• Enzymology Studies: Serves as a substrate or modulator for phosphodiesterases (PDEs) and protein kinases (PKG) to study enzyme kinetics and inhibition.
• Cell Physiology: Investigation of cellular processes such as smooth muscle relaxation, platelet aggregation, and neuronal signal transduction.
• Probe Development: Utilized in the synthesis of labeled probes (e.g., fluorescent, radioactive) for imaging and detection applications.
• Reference Standard: Acts as an analytical standard for quality control and method validation in pharmaceutical and research laboratories.

Basic Information

Product Name	Rp-8-Bromo-Cyclic GMPS (Sodium Salt)
CAS No.	208445-06-1
Molecular Formula	C10H11BrN5NaO7P
Molecular Weight	463.09 g/mol
Synonyms	Rp-8-Br-cGMPS sodium salt; 8-Bromoguanosine-3',5'-cyclic monophosphorothioate, Rp-isomer, sodium salt; Rp-8-Bromo-cyclic guanosine monophosphorothioate sodium; Rp-8-Br-cGMPS; 8-Bromo-cGMPS Rp isomer sodium salt; Guanosine, 8-bromo-3',5'-(hydrogen phosphorothioate), Rp-isomer, sodium salt; cGMP analog Rp-8-Bromo; Rp-8-Bromo-cyclic GMPS Na+
EINECS	Contact for details

Quality Control

Our Rp-8-Bromo-Cyclic GMPS (Sodium Salt) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent tests for residual solvents and moisture content. We provide full traceability and a detailed Certificate of Analysis (COA) with every shipment to ensure it meets the exacting standards required for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solvent Residues (GC)	Meets ICH guidelines
Biological Activity	Tested in standard kinase/PDE assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.