Description

Hexadimethrine Bromide is a cationic polymer widely recognized for its potent polycationic properties, making it an essential reagent in molecular biology and biotechnology. Its primary value lies in its ability to neutralize negative charges on cell surfaces and nucleic acids, facilitating critical processes like transfection and precipitation. This compound is particularly vital for research laboratories, pharmaceutical development, and bioproduction facilities focused on gene delivery and vaccine development.

Application

• Cell Transfection Reagent: Used as a polycationic agent to enhance the delivery of DNA, RNA, and other nucleic acids into mammalian cells in vitro.
• Viral Vector Production: Acts as a precipitation agent in the purification and concentration of retroviruses and lentiviruses for gene therapy applications.
• Nucleic Acid Precipitation: Facilitates the precipitation of DNA and RNA from dilute solutions, often as an alternative to traditional alcohol-based methods.
• Cell Biology Studies: Employed to study cell membrane interactions and to promote cell adhesion to culture surfaces.
• Biopharmaceutical Processing: Used in downstream purification steps to remove contaminants like endotoxins and host cell nucleic acids.
• Polymer Chemistry Research: Serves as a model cationic polymer for studying polyelectrolyte complexes and drug delivery systems.

Basic Information

Product Name	Hexadimethrine Bromide
CAS No.	28728-55-4
Molecular Formula	(C13H30N2)n • 2nBr
Molecular Weight	~ 6,000 - 10,000 g/mol (average)
Synonyms	Polybrene; 1,5-Dimethyl-1,5-diazaundecamethylene polymethobromide; Poly(1,5-dimethyl-1,5-diazaundecamethylene) bromide; Poly[(dimethylimino)(2-hydroxy-1,3-propanediyl) chloride]; Hexadimethrine; Polycation; Poly-DADMAC (related polymer class); Aldrithiol-4 (historical trade name)
EINECS	249-220-0

Quality Control

Our Hexadimethrine Bromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and performance consistency suitable for critical research and bioprocessing applications. A comprehensive Certificate of Analysis (COA) detailing assay, impurity profile, and functional performance data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at room temperature (15-25°C) in a cool, dry, and well-ventilated area. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent absorption of atmospheric moisture, which may affect performance.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to reference spectrum
Assay (Nitrogen Content)	≥ 95.0 %
pH (1% Solution)	6.0 - 8.0
Loss on Drying	≤ 5.0 %
Residue on Ignition	≤ 1.0 %
Biological Activity (Transfection)	Meets performance criteria

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.