Description

Phorbol 12,13-Didecanoate is a synthetic diester derivative of the natural phorbol diterpene, widely recognized as a potent and specific activator of Protein Kinase C (PKC). This compound is crucial for biomedical research, enabling the study of PKC-mediated signal transduction pathways in cellular models. It is primarily utilized by researchers and developers in the fields of pharmacology, oncology, and cell biology for investigating mechanisms related to cell proliferation, tumor promotion, and inflammatory responses.

Application

• Biomedical Research: A key tool compound for activating Protein Kinase C (PKC) isoforms in cell-based assays and signal transduction studies.
• Oncology Research: Used to study PKC's role in tumor promotion, cell proliferation, and apoptosis in various cancer cell lines.
• Pharmacology & Drug Discovery: Serves as a reference standard and positive control in screening assays for PKC inhibitors and modulators.
• Cell Biology Studies: Applied in research on cellular differentiation, immune response, and inflammatory pathways mediated by PKC activation.
• Biochemical Assay Development: Utilized in the development and validation of in vitro enzymatic assays for PKC activity.
• Academic & Institutional Research: Essential for universities and research institutes conducting fundamental studies in molecular biology and biochemistry.

Basic Information

Product Name	Phorbol 12,13-Didecanoate
CAS No.	24928-17-4
Molecular Formula	C40H64O8
Molecular Weight	672.9 g/mol
Synonyms	PDD; Phorbol 12,13-Didecanoate; 12,13-Didecanoylphorbol; 12-O-Tetradecanoylphorbol-13-decanoate (common misnomer); 4,9,12-beta,13-alpha,20-Pentahydroxytiglia-1,6-dien-3-one 12,13-didecanoate; TPA analog; Protein Kinase C Activator I; NSC 357753
EINECS	Contact for details

Quality Control

Our Phorbol 12,13-Didecanoate is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability, purity, and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. The product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a desiccator to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.