Description

Phorbol-12-Monomyristate is a potent and specific protein kinase C (PKC) activator widely used as a critical biochemical tool in life science research. Its value lies in its ability to reliably induce cellular responses, making it indispensable for studying signal transduction pathways, cell proliferation, and tumor promotion mechanisms. This high-purity compound is essential for researchers and developers in pharmaceutical R&D, academic institutions, and biotechnology companies focusing on cancer biology, immunology, and inflammatory disease models.

Application

• Biomedical Research: As a standard PKC activator for studying intracellular signaling cascades, cell differentiation, and apoptosis.
• Cancer Biology Studies: Used to investigate tumor promotion mechanisms and the role of PKC isoforms in various cancer cell lines.
• Immunology & Inflammation Research: Employed to activate T-cells, neutrophils, and other immune cells to model inflammatory responses.
• Pharmacology & Drug Discovery: Serves as a key reference compound and positive control in high-throughput screening for PKC inhibitor development.
• Cell Culture & Molecular Biology: Applied to induce specific gene expression and enzyme activity in controlled experimental settings.
• Toxicology Studies: Utilized as a model compound for investigating skin irritation and co-carcinogenic effects.

Basic Information

Product Name	Phorbol-12-Monomyristate
CAS No.	20839-06-9
Molecular Formula	C36H56O8
Molecular Weight	616.83 g/mol
Synonyms	PMA; TPA; 12-O-Tetradecanoylphorbol-13-acetate; Phorbol 12-Myristate 13-Acetate; NSC 350836; 12-O-Tetradecanoylphorbol-13-acetate; 12-O-Tetradecanoyl-4beta,9alpha,13alpha,20-tetrahydroxy-1,6-tigliadien-3-one 13-acetate
EINECS	244-087-4

Quality Control

Our Phorbol-12-Monomyristate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and spectroscopic methods for structural confirmation. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your research documentation and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. The product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Solubility	Soluble in DMSO, ethanol, acetone; insoluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.