Description

2'3'-Cgamp CAS NO 1441190-66-4 is a specialized cyclic dinucleotide (CDN) analog, a high-purity biochemical crucial for modulating the innate immune response via the STING (Stimulator of Interferon Genes) pathway. Its precise structure makes it a powerful tool for advanced immunology research and therapeutic development. This compound is essential for researchers and developers in the pharmaceutical and biotechnology sectors focusing on novel cancer immunotherapies, vaccine adjuvants, and treatments for autoimmune diseases.

Application

• STING Pathway Agonist Research: Fundamental tool for studying the activation and regulation of the cGAS-STING signaling pathway in immunology.
• Cancer Immunotherapy Development: Investigated as a potential intratumoral injectable to stimulate anti-tumor immune responses and enhance the efficacy of checkpoint inhibitors.
• Vaccine Adjuvant Research: Explored for its ability to potentiate immune responses in next-generation vaccine formulations, particularly for viral and cancer vaccines.
• Inflammatory & Autoimmune Disease Models: Used to induce and study controlled interferon production and inflammation in preclinical models of disease.
• Drug Discovery Screening: Serves as a reference standard and active compound in high-throughput screening assays for novel STING modulators.
• Cell-Based Assays: Applied in vitro to stimulate interferon-beta (IFN-β) production in immune cells like macrophages and dendritic cells.

Basic Information

Product Name	2'3'-Cgamp
CAS No.	1441190-66-4
Molecular Formula	C20H24N10O14P2
Molecular Weight	690.40 g/mol
Synonyms	2'3'-cyclic GMP-AMP; 2',3'-cGAMP; 2'3'-cyclic guanosine monophosphate–adenosine monophosphate; Cyclic [G(2',5')pA(3',5')p]; 2'3'-cGAMP sodium salt (if applicable); STING agonist cyclic dinucleotide; cGAMP isomer; 2'-3'-CGAMP
EINECS	Contact for details

Quality Control

Our 2'3'-Cgamp is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality guidelines for research-grade biochemicals, ensuring reliable and reproducible performance in your assays.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, keep under inert atmosphere or in a vacuum desiccator.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water or buffer, slightly soluble in DMSO
Biological Activity (Cell-based assay)	Induces IFN-β production in THP1 cells (EC50 provided on COA)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.