Description

Cilliobrevin D CAS NO 1370554-01-0 is a potent and selective small molecule inhibitor of the AAA+ ATPase, cytoplasmic dynein 1. This compound matters as a critical research tool for dissecting intracellular transport mechanisms, mitotic spindle assembly, and neuronal function. It is needed by researchers in the fields of cell biology, neurobiology, and pharmacology for target validation and pathway analysis.

Application

• Cell Biology Research: Used to study the role of cytoplasmic dynein in intracellular cargo transport, organelle positioning, and mitotic processes.
• Neuroscience Studies: Employed to investigate axonal transport, synaptic vesicle trafficking, and the molecular basis of neurodegenerative diseases.
• Drug Discovery & Target Validation: Serves as a pharmacological probe to validate dynein as a therapeutic target in cancer and neurological disorders.
• Developmental Biology: Applied in research on cell division, polarity establishment, and embryonic development where dynein function is crucial.
• Virology Research: Utilized to study viral trafficking and replication mechanisms that hijack the host cell's dynein motor complex.

Basic Information

Product Name	Cilliobrevin D
CAS No.	1370554-01-0
Molecular Formula	C₁₉H₁₈N₂O₃
Molecular Weight	322.36 g/mol
Synonyms	Ciliobrevin D; Dynein Inhibitor, Ciliobrevin D; 2-[(2,3-Dihydro-1,4-benzodioxin-6-yl)carbonyl]-2,3-dihydro-1H-indole-1-carboxamide; AAA+ ATPase Inhibitor; Cytoplasmic Dynein 1 Inhibitor
EINECS	Contact for details

Quality Control

Our Cilliobrevin D is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and NMR for structural confirmation. A Certificate of Analysis (COA) detailing identity, purity, and assay results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.