Description

n-(4-Carboxybenzyl)-N,n-Dimethyl-2,3-Bis(Oleoyloxy)Propan-1-Aminium is a specialized cationic lipid compound with a unique molecular architecture combining a quaternary ammonium head group with oleoyl chains. This structure is critical for its primary function as a key functional excipient in advanced drug delivery systems, particularly for nucleic acid therapeutics. It is essential for research and development teams in the pharmaceutical and biotechnology sectors who require high-purity, reliable materials for formulating lipid nanoparticles (LNPs) for mRNA, siRNA, and gene therapy applications.

Application

• Lipid Nanoparticle (LNP) Formulation: A critical cationic lipid component for the encapsulation and delivery of mRNA vaccines and therapeutics.
• Gene Therapy Vectors: Used in the development of non-viral delivery systems for plasmid DNA (pDNA) and CRISPR-Cas9 components.
• siRNA Delivery: Facilitates the cellular uptake and endosomal escape of small interfering RNA (siRNA) for gene silencing applications.
• Biomedical Research: Serves as a key reagent in academic and industrial R&D for studying novel transfection and delivery mechanisms.
• Cosmetic & Dermatological Actives Delivery: Potential use in advanced cosmetic formulations for enhanced skin penetration of active ingredients.

Basic Information

Product Name	n-(4-Carboxybenzyl)-N,n-Dimethyl-2,3-Bis(Oleoyloxy)Propan-1-Aminium
CAS No.	1360461-69-3
Molecular Formula	C54H92N2O6+ • X-
Molecular Weight	Contact for details
Synonyms	Carboxybenzyl-Dimethyl-Oleoyl Propanaminium; (9Z,9'Z)-N-(4-Carboxybenzyl)-N,N-dimethyl-2,3-bis((9Z)-octadec-9-enoyloxy)propan-1-aminium; Cationic Lipid 1360461-69-3; 1-Propanaminium, N-(4-carboxybenzyl)-N,N-dimethyl-2,3-bis[(1-oxo-9-octadecen-1-yl)oxy]-, (9Z,9'Z)-; Oleoyl-based cationic lipid; mRNA delivery lipid excipient; LNP cationic component
EINECS	Contact for details

Quality Control

Our production of n-(4-Carboxybenzyl)-N,n-Dimethyl-2,3-Bis(Oleoyloxy)Propan-1-Aminium adheres to stringent quality protocols suitable for pharmaceutical development. Each batch is characterized and tested to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications such as assay, related substances, and residual solvents are provided. We support compliance with cGMP and ICH guidelines for drug substance intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) to minimize oxidation and hydrolysis. For long-term storage, desiccate. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.