Description

4-(4-Fluoro-3-Methylphenyl)Benzonitrile is a high-purity, advanced pharmaceutical intermediate characterized by its benzonitrile core substituted with a fluoro-methylphenyl group. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular architecture. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for developing new drug candidates and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel small-molecule drugs, especially kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Research: Serves as a precursor in the development of new-generation herbicides and pesticides with optimized activity and environmental profiles.
• Liquid Crystal & OLED Materials: Used in the research and production of advanced electronic display materials due to its stable, aromatic structure.
• Organic Synthesis: A versatile reagent for constructing complex aromatic systems in academic and industrial research laboratories.
• Fluorine Chemistry Studies: Employed as a model compound in studying the effects of fluorine substitution on molecular properties and reactivity.

Basic Information

Product Name	4-(4-Fluoro-3-Methylphenyl)Benzonitrile
CAS No.	1352318-42-3
Molecular Formula	C14H10FN
Molecular Weight	211.24 g/mol
Synonyms	4-(4-Fluoro-3-methylphenyl)benzonitrile; [1,1'-Biphenyl]-4-carbonitrile, 4'-fluoro-3'-methyl-; 4'-Fluoro-3'-methyl[1,1'-biphenyl]-4-carbonitrile; 4-Cyano-4'-fluoro-3'-methylbiphenyl; p-Cyano-p'-fluoro-m'-methylbiphenyl
EINECS	Contact for details

Quality Control

Our 4-(4-Fluoro-3-Methylphenyl)Benzonitrile is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.