Description

Npec-Caged-(1S,3R)-Acpd is a specialized caged glutamate analog designed for precise, light-triggered release in advanced neuroscience research. This compound matters as a critical photolabile tool for studying the spatial and temporal dynamics of metabotropic glutamate receptor (mGluR) signaling. Researchers in neuropharmacology, systems biology, and drug discovery need it for high-resolution, controlled activation of neuronal pathways to investigate synaptic plasticity, neurological disorders, and receptor function.

Application

• Photopharmacology Research: Enables light-controlled activation of group I metabotropic glutamate receptors (mGluR1/5) with high temporal precision.
• Neuroscience & Neurobiology: Used to map and manipulate neuronal circuits to study synaptic transmission, plasticity (LTP/LTD), and signal integration.
• Cellular Signaling Studies: Investigates the role of mGluR-mediated pathways in intracellular calcium mobilization and second messenger systems.
• Drug Discovery Platforms: Serves as a key tool compound for validating targets and screening potential therapeutics for neurological conditions.
• High-Resolution Imaging: Facilitates uncaging experiments combined with techniques like two-photon microscopy for subcellular receptor studies.

Basic Information

Product Name	Npec-Caged-(1S,3R)-Acpd
CAS No.	1315379-60-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(1S,3R)-1-Aminocyclopentane-1,3-dicarboxylic acid, 1-(4-Nitrophenethyl) ester; (1S,3R)-ACPD, NPE-caged; NPE-(1S,3R)-ACPD; Caged (1S,3R)-ACPD; 4-Nitrophenethyl-caged (1S,3R)-ACPD; Photolabile (1S,3R)-ACPD; Light-activatable mGluR agonist
EINECS	Contact for details

Quality Control

Our Npec-Caged-(1S,3R)-Acpd is manufactured under strict quality protocols to ensure batch-to-batch consistency and research reliability. Each lot undergoes comprehensive analytical characterization, including HPLC for purity verification and spectroscopic methods for structural confirmation. A Certificate of Analysis (COA) detailing identity, purity, and stability is provided with every shipment to support your experimental integrity and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is strictly light-sensitive and must be handled under appropriate light conditions (e.g., amber glass, low-actinic lighting) to maintain stability. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥95%
Water Content	≤1.0%
Solubility	Soluble in DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.