Description

(±)-Jq1 CAS NO 1268524-69-1 is a potent and selective small molecule inhibitor of the bromodomain and extra-terminal (BET) family of proteins, specifically targeting BRD4. This compound is a critical research tool for investigating epigenetic regulation, gene transcription, and their roles in various disease pathways. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in oncology, immunology, and inflammation research to explore novel therapeutic targets and mechanisms.

Application

• Epigenetics Research: Used as a standard BET bromodomain inhibitor to study chromatin remodeling and transcriptional regulation.
• Oncology Studies: Investigated for its potential to suppress cancer cell proliferation and tumor growth in preclinical models, particularly in hematological and solid tumors.
• Immunology & Inflammation Research: Applied to modulate inflammatory gene expression and cytokine production in immune cell studies.
• Chemical Biology: Serves as a key pharmacological probe to validate BRD4-dependent cellular processes and signaling networks.
• Drug Discovery & Development: Used in high-throughput screening (HTS) and lead optimization campaigns for developing novel BET-targeted therapeutics.
• Mechanistic Studies: Essential for understanding the role of BET proteins in diseases such as heart failure, fibrosis, and metabolic disorders.

Basic Information

Product Name	(±)-Jq1
CAS No.	1268524-69-1
Molecular Formula	C₂₃H₂₃ClN₄O₂S
Molecular Weight	454.97 g/mol
Synonyms	(±)-JQ1; JQ-1 (racemate); (Rac)-JQ1; BRD4 Inhibitor JQ1 (±); 4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid 1,1-dimethylethyl ester; BET Bromodomain Inhibitor JQ1; Thienotriazolodiazepine JQ1
EINECS	Contact for details

Quality Control

Our (±)-Jq1 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high purity and structural identity. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with our rigorous in-house specifications. We support research reproducibility with consistent quality and full traceability.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.