Description

(2S)-Ompt is a stereospecific organic compound widely utilized as a chiral building block and advanced intermediate in pharmaceutical synthesis. Its high enantiomeric purity enables precise control over stereochemistry in active pharmaceutical ingredient (API) development—critical for efficacy, safety, and regulatory approval. Global pharmaceutical R&D laboratories, contract development and manufacturing organizations (CDMOs), and fine chemical manufacturers rely on this material for the synthesis of protease inhibitors, antiviral agents, and other biologically active molecules. The compound is referenced in technical literature and regulatory submissions under (2S)-Ompt CAS NO 1217471-69-6.

Application

• Chiral auxiliary in asymmetric synthesis of HIV protease inhibitors
• Key intermediate for the manufacture of anticoagulant and antithrombotic drug candidates
• Enantioselective catalyst ligand precursor in transition-metal-catalyzed C–N bond formation
• Building block for peptide mimetics and macrocyclic therapeutics
• Research reagent in structure–activity relationship (SAR) studies targeting serine proteases
• Starting material for GMP-compliant API process development under ICH Q5–Q7 guidelines
• Custom synthesis support for oncology and immunology pipeline compounds
• Stability-indicating reference standard in HPLC method validation

Basic Information

Product Name	(2S)-Ompt
CAS No.	1217471-69-6
Molecular Formula	C₁₈H₂₀N₂O₄
Molecular Weight	328.36 g/mol
Synonyms	(2S)-2-[(Benzyloxy)carbonylamino]-3-(4-nitrophenyl)propanoic acid; (2S)-N-Cbz-β-(4-nitrophenyl)alanine; (2S)-N-(Benzyloxycarbonyl)-β-(p-nitrophenyl)alanine; (2S)-N-Carbobenzoxy-β-(4-nitrophenyl)alanine; (2S)-Cbz-β-(4-NO₂-C₆H₄)Ala-OH; (2S)-2-[(Phenylmethoxy)carbonylamino]-3-(4-nitrophenyl)propanoic acid; L-β-(4-Nitrophenyl)alanine N-Cbz derivative; (S)-N-Cbz-β-(p-nitrophenyl)alanine
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches meet stringent specifications for enantiomeric excess (≥99.5% ee), assay (≥99.0%), residual solvents (≤500 ppm total), heavy metals (≤10 ppm), and microbial limits (absent in 1g). Testing follows validated methods aligned with USP & EP monographs, ICH Q2(R2), and GMP Annex 19 requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 15–25°C in a dry, well-ventilated area. Due to its hygroscopic nature, minimize exposure to ambient humidity; use desiccated storage conditions during handling and dispensing.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Odor	Characteristic, faint aromatic
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	99.0 – 101.0%
Enantiomeric Excess (Chiral HPLC)	≥99.5%
Residual Solvents (GC)	Meets ICH Q3C Class 3 limits
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Sulfated Ash	≤0.1%
Microbial Limits	Total aerobic count ≤100 CFU/g; absence of E. coli, Salmonella, and Staphylococcus aureus

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.