Description

(R)-4-(1-Amino-2-Hydroxyethyl)-2,6-Difluorobenzonitrile is a high-value chiral intermediate characterized by its benzonitrile core with difluoro substitution and an amino alcohol side chain. This compound is critical for the synthesis of complex molecules where stereochemical purity directly impacts biological activity and process efficiency. It is primarily sought after by pharmaceutical R&D and production teams for the development of active pharmaceutical ingredients (APIs), particularly in therapeutic areas such as oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel, optically active drug candidates and APIs.
• Asymmetric Synthesis: Utilized in catalytic and stoichiometric asymmetric reactions to introduce stereocenters with high enantiomeric excess.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Precursor for Fluorinated Compounds: The difluoro aromatic moiety makes it a valuable precursor for synthesizing more complex fluorinated molecules with enhanced metabolic stability and bioavailability.
• Chemical Biology Probes: Used in the development of labeled compounds and probes for studying biological mechanisms and target engagement.

Basic Information

Product Name	(R)-4-(1-Amino-2-Hydroxyethyl)-2,6-Difluorobenzonitrile
CAS No.	1213607-78-3
Molecular Formula	C9H8F2N2O
Molecular Weight	198.17 g/mol
Synonyms	(R)-2-Amino-1-(3,5-difluoro-4-cyanophenyl)ethanol; (R)-4-(1-Amino-2-hydroxyethyl)-2,6-difluorobenzonitrile; (R)-2,6-Difluoro-4-(1-amino-2-hydroxyethyl)benzonitrile; (R)-α-(Aminomethyl)-3,5-difluoro-4-hydroxybenzyl alcohol (tautomer); (R)-1-(3,5-Difluoro-4-cyanophenyl)-2-aminoethanol; (R)-Enantiomer of 4-(1-Amino-2-hydroxyethyl)-2,6-difluorobenzonitrile; (R)-Amino alcohol intermediate 1213607-78-3
EINECS	Contact for details

Quality Control

Our (R)-4-(1-Amino-2-Hydroxyethyl)-2,6-Difluorobenzonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP production. A detailed Certificate of Analysis (COA) providing specifications for identity, purity (HPLC), enantiomeric excess (Chiral HPLC), and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere to prevent degradation. For long-term storage, consider storing under an inert gas such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.