Description

U0126-Etoh CAS NO 1173097-76-1 is a highly specific and potent inhibitor of the MEK1/2 (MAPK/ERK kinase) signaling pathway. This compound is critical for researchers and developers in life sciences, as it enables precise control and study of the MAPK cascade, a key regulator of cell proliferation, differentiation, and survival. It is an essential tool for pharmaceutical R&D, academic research, and biotechnology applications focused on oncology, neurology, and inflammatory diseases.

Application

• Biochemical Research: A standard tool for selectively inhibiting MEK1 and MEK2 to study the role of the MAPK/ERK pathway in cellular signaling and disease models.
• Pharmaceutical Development: Used in target validation and as a reference compound in the discovery of novel oncology and anti-inflammatory therapeutics.
• Cell Biology Studies: Applied in vitro to investigate mechanisms of cell cycle progression, apoptosis, and differentiation in various cell lines.
• Academic Research: Utilized in universities and research institutes for fundamental studies on signal transduction and molecular biology.
• Preclinical Studies: Serves as a pharmacological agent in animal models to explore the therapeutic potential of MEK inhibition.

Basic Information

Product Name	U0126-Etoh
CAS No.	1173097-76-1
Molecular Formula	C16H18N4O2 • C2H6O
Molecular Weight	380.45 g/mol
Synonyms	U0126 Ethanolate; U-0126; 1,4-Diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene ethanolate; MEK1/2 Inhibitor U0126; U0126 (MEK1/2 Inhibitor); U0126-EtOH; U0126 Ethanol Solvate; MAPK Inhibitor U0126
EINECS	Contact for details

Quality Control

Our U0126-Etoh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature in a dry environment before opening.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, Ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.