Description

Grb2 Sh2 Domain Ligand is a specialized, high-purity biochemical compound designed for advanced life science research and pharmaceutical development. This compound serves as a critical tool for studying and modulating intracellular signaling pathways, specifically those involving the Grb2 adaptor protein and its SH2 domain interactions. It is essential for researchers and developers in academic institutions, pharmaceutical R&D, and biotechnology companies focused on oncology, immunology, and signal transduction mechanisms. The product is supplied with guaranteed quality and stability for reproducible experimental results.

Application

• Biochemical Research: Used as a specific inhibitor or ligand in studies of Grb2-mediated signal transduction pathways.
• Drug Discovery & Development: Serves as a key reference standard or starting material in screening assays for novel therapeutics targeting protein-protein interactions.
• Enzymology Studies: Employed to investigate the kinetics and specificity of SH2 domain binding and function.
• Cellular Signaling Analysis: A vital reagent for probing the role of Grb2 in growth factor receptor signaling, cell proliferation, and differentiation.
• Proteomics & Molecular Biology: Utilized in pull-down assays, affinity chromatography, and other techniques to isolate and identify interacting proteins.
• Academic & Contract Research: Supplied to university labs and CROs for fundamental and applied research in cancer biology and related fields.

Basic Information

Product Name	Grb2 Sh2 Domain Ligand
CAS No.	168423-05-0
Molecular Formula	C24H31N5O9S
Molecular Weight	565.60 g/mol
Synonyms	Fmoc-Asp(OtBu)-Tyr(PO(OMe)2)-Glu(OtBu)-OH; Phosphotyrosine Peptide Ligand for Grb2 SH2 Domain; Fmoc-D-Y(PO(OMe)2)-E-OtBu; Grb2 SH2 Domain Binding Peptide; SH2 Domain Inhibitor; 4-Phosphonodifluoromethyl-DL-phenylalanine-containing peptide derivative; EGFR-derived phosphopeptide ligand.
EINECS	Contact for details

Quality Control

Our Grb2 Sh2 Domain Ligand is manufactured under controlled conditions to ensure the highest standards of purity and batch-to-batch consistency. Each lot undergoes rigorous analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and NMR for structural verification. We adhere to stringent in-house quality protocols to meet the exacting requirements of research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.