Description

L-α-D-Myo-Phosphatidylinositol 3,4,5-Triphosphate Di C8 is a synthetic, short-chain diacylglycerol analog of the critical second messenger phosphatidylinositol (3,4,5)-trisphosphate (PIP3). This compound is essential for fundamental biochemical research, particularly in studying intracellular signaling pathways related to cell growth, proliferation, and survival. It serves as a vital tool for researchers and pharmaceutical developers in cell biology, signal transduction studies, and drug discovery targeting kinases like PI3K and related diseases such as cancer and metabolic disorders.

Application

• Biochemical Research Reagent: A critical substrate and standard for studying phosphatidylinositol 3-kinase (PI3K) and related signaling cascades.
• Enzyme Kinetics & Assay Development: Used as a substrate in in vitro enzymatic assays to measure PI3K, PTEN, or SHIP phosphatase activity.
• Lipidomics & Mass Spectrometry: Employed as an analytical standard for the identification and quantification of phosphoinositides in complex biological samples.
• Drug Discovery & Screening: Utilized in high-throughput screening (HTS) platforms to identify and characterize novel inhibitors or activators of the PI3K/Akt/mTOR pathway.
• Cell Signaling Studies: Applied in cellular models to investigate the role of PIP3 in processes like cell migration, insulin signaling, and apoptosis.
• Liposome & Membrane Biophysics: Incorporated into synthetic lipid bilayers or liposomes to study protein-lipid interactions and membrane dynamics.

Basic Information

Product Name	L-α-D-Myo-Phosphatidylinositol 3,4,5-Triphosphate Di C8
CAS No.	163563-77-7
Molecular Formula	C23H43O19P3
Molecular Weight	740.48 g/mol
Synonyms	PIP3 (C8); PI(3,4,5)P3 DiC8; D-myo-Inositol 1,3,4,5-tetrakisphosphate, 2-(octanoyloxy)-3-(octanoyloxy)propyl hydrogen phosphate; 1,2-Di-O-octanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate); Phosphatidylinositol (3,4,5)-trisphosphate (C8); PtdIns(3,4,5)P3 DiC8; Synthetic PIP3 analog; L-α-D-myo-Phosphatidylinositol-3,4,5-trisphosphate diC8
EINECS	Contact for details

Quality Control

Our high-purity biochemical reagents are produced and analyzed under stringent conditions to ensure reproducible performance in sensitive research applications. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm structural identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your research integrity and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive) and easily oxidized; it is recommended to store under an inert atmosphere and allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (HPLC/MS)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95% (Area Percent)
Solubility	Soluble in chloroform/methanol mixtures

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.