Description

8-Bromoguanosine-3',5'-Cyclic Monophosphorothioate, Rp-Isomer Sodium Salt is a chemically modified nucleotide analog of cyclic GMP (cGMP), where a sulfur atom replaces one of the non-bridging oxygen atoms in the phosphate group and a bromine atom is introduced at the 8-position of the guanine base. This specific Rp-isomer is a crucial potent and selective activator of cGMP-dependent protein kinase (PKG), making it an indispensable tool for probing intracellular signaling pathways. It is primarily used by pharmaceutical researchers, biochemical assay developers, and academic institutions focused on cardiovascular biology, neurobiology, and smooth muscle physiology.

Application

• Biochemical Research: As a potent and selective activator of cGMP-dependent protein kinase (PKG) in cell-free systems and purified enzyme assays.
• Cell Signaling Studies: To investigate the role of PKG in pathways regulating vascular tone, platelet aggregation, and neuronal plasticity.
• Drug Discovery & Screening: Used in high-throughput screening (HTS) assays to identify novel modulators of the PKG pathway for therapeutic development.
• Physiology & Pharmacology: A key tool for studying smooth muscle relaxation, cardiac function, and other processes mediated by cGMP signaling.
• Reference Standard: Serves as an analytical standard for quality control and method development in laboratories synthesizing or using nucleotide analogs.

Basic Information

Product Name	8-Bromoguanosine-3',5'-Cyclic Monophosphorothioate, Rp-Isomer Sodium Salt
CAS No.	150418-07-8
Molecular Formula	C10H11BrN5NaO6PS
Molecular Weight	470.16 g/mol
Synonyms	8-Br-cGMPS, Rp-isomer; Rp-8-Bromo-cGMPS sodium salt; Rp-8-Br-cGMPS; 8-Bromo-guanosine-3',5'-cyclic monophosphorothioate, Rp-isomer sodium salt; Sodium (Rp)-8-bromoguanosine-3',5'-cyclic phosphorothioate; PKG Activator; cGMP-dependent protein kinase activator; 8-Bromoguanosine cyclic 3',5'-(hydrogen phosphorothioate) Rp-isomer sodium salt
EINECS	Contact for details

Quality Control

Our 8-Bromoguanosine-3',5'-Cyclic Monophosphorothioate, Rp-Isomer Sodium Salt is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and isomer specificity, NMR for structural confirmation, and mass spectrometry for identity verification. Certificates of Analysis (COA) detailing all specifications are provided to ensure reproducibility and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Isomeric Purity (Rp-isomer)	≥ 98%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.