Description

Adenophostin A CAS NO 149091-92-9 is a potent and selective inositol 1,4,5-trisphosphate (IP3) receptor agonist, functioning as a stable, cell-permeable analog of the natural second messenger D-myo-inositol 1,4,5-trisphosphate. This compound is a critical research tool for investigating intracellular calcium signaling pathways, which are fundamental to numerous physiological and pathological processes. It is primarily utilized by researchers and developers in the fields of cell biology, pharmacology, and neuroscience to study receptor activation, calcium mobilization, and related cellular events.

Application

• Biochemical Research: A key tool for studying the structure, function, and pharmacology of inositol 1,4,5-trisphosphate (IP3) receptors in vitro.
• Cell Signaling Studies: Used to probe intracellular calcium (Ca²⁺) release mechanisms and signal transduction cascades in various cell types.
• Neuroscience Research: Investigates the role of IP3-mediated calcium signaling in neuronal function, synaptic plasticity, and neurodegenerative disease models.
• Pharmacological Profiling: Serves as a reference agonist for screening and characterizing novel modulators of the IP3 receptor pathway.
• Cardiovascular Research: Applied in studies of calcium-induced calcium release in cardiac and smooth muscle cells.
• Drug Discovery: Used in target validation and mechanistic studies for diseases where dysregulated calcium signaling is implicated.

Basic Information

Item	Detail
Product Name	Adenophostin A
CAS No.	149091-92-9
Molecular Formula	C₂₀H₂₆N₅O₁₇P₃
Molecular Weight	701.36 g/mol
Synonyms	3''-O-Phosphonoadenophostin A; Adenosine 3'',5''-bis(dihydrogen phosphate) derivative; 2-O-(6-Deoxy-6-{[(phosphonooxy)acetyl]amino}-α-D-glucopyranosyl)-1-O-[6-(6-aminopurin-9-yl)-6-deoxy-2-O-phosphono-α-D-glucofuranosyl]-myo-inositol 1,4,5-trisphosphate; IP3 Receptor Agonist; D-myo-Inositol 1,4,5-trisphosphate analog
EINECS	Contact for details

Quality Control

Our Adenophostin A is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and structural confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) documenting identity, purity, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic nature, allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥95%
Water Content (KF)	≤5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.